Addition of Vitamin B to Dexketoprofen to Manage Cervical Muscle Sprain Pain
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on November 14th, 2025
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Cervical muscle pain is commonly treated with non-steroidal anti-inflammatory drugs (NSAIDs) and muscle relaxants; however, these therapies often provide limited relief and are associated with considerable adverse effects. To identify alternative treatment options, the pharmaceutical company, Laboratorios Silanes, funded a study investigating the potential benefit of adding a vitamin B complex supplement to dexketoprofen therapy.
This phase 3 clinical trial enrolled 170 participants with a mean age of 42.3 years who had been diagnosed with grade I–II cervical muscle sprain according to the Quebec criteria. The majority (79.3%) sustained a flexion-extension injury, and 77.1% presented with moderate contracture. Baseline assessments using the Visual Analogue Scale (VAS) and the Northwick Park Neck Pain Questionnaire (NPQ) yielded average scores of 7.2 and 41, respectively.
All participants received 25 mg of oral dexketoprofen every eight hours and were randomly assigned to receive either placebo or a vitamin B complex capsule containing 100 mg thiamine, 50 mg pyridoxine, and 0.5 mg cyanocobalamin, taken concurrently. B vitamins are hypothesized to modulate pain perception by influencing neurotransmitter synthesis and enhancing anti-inflammatory pathways. After seven days of treatment, the addition of vitamin B complex to dexketoprofen significantly improved pain alleviation, as observed in significant reduction on both the VAS and NPQ compared with placebo. Moreover, patients receiving vitamin B reported fewer gastrointestinal side effects, including gastritis and gastric irritation, suggesting improved tolerability of the regimen.
This phase 3 clinical trial enrolled 170 participants with a mean age of 42.3 years who had been diagnosed with grade I–II cervical muscle sprain according to the Quebec criteria. The majority (79.3%) sustained a flexion-extension injury, and 77.1% presented with moderate contracture. Baseline assessments using the Visual Analogue Scale (VAS) and the Northwick Park Neck Pain Questionnaire (NPQ) yielded average scores of 7.2 and 41, respectively.
All participants received 25 mg of oral dexketoprofen every eight hours and were randomly assigned to receive either placebo or a vitamin B complex capsule containing 100 mg thiamine, 50 mg pyridoxine, and 0.5 mg cyanocobalamin, taken concurrently. B vitamins are hypothesized to modulate pain perception by influencing neurotransmitter synthesis and enhancing anti-inflammatory pathways. After seven days of treatment, the addition of vitamin B complex to dexketoprofen significantly improved pain alleviation, as observed in significant reduction on both the VAS and NPQ compared with placebo. Moreover, patients receiving vitamin B reported fewer gastrointestinal side effects, including gastritis and gastric irritation, suggesting improved tolerability of the regimen.