Increase the Effectiveness of E-Cigarette Cessation with Cytisinicline
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on June 24th, 2024
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With the increase in popularity in vaping and e-cigarette containing nicotine, regulatory agencies have identified that there is a gap in knowledge on the effectiveness of nicotine replacement therapy on e-cigarette cessation. Cytisinicline is an agonist that can inhibit the α4β2 nicotinic acetylcholine receptors which can reduce the dependence on nicotine. As a result, the National Institute of Drug Abuse had funded a study to assess the efficacy of cytisinicline on vaping cessation.
The phase 2 clinical trial included 160 adults with an average age of 33.6 years old who had reported to use e-cigarette daily with a saliva cotinine level above 30 ng/mL. The participants were randomly treated orally with either placebo or 3 mg of cytisinicline daily for 12 weeks. At the end of the treatment period, the researchers found that 31.8% of those treated with cytisinicline were able to maintain e-cigarette abstinence; significantly higher than the 15.1% cessation rate found in the placebo group. However, observation was made at the 16th week, the 4 weeks without treatment might have removed the difference between the groups, as the percentage of people who can cease e-cigarette use decreased to 23.4%. The researchers concluded that a larger study is needed to further elucidate the effectiveness of cytisinicline.
The phase 2 clinical trial included 160 adults with an average age of 33.6 years old who had reported to use e-cigarette daily with a saliva cotinine level above 30 ng/mL. The participants were randomly treated orally with either placebo or 3 mg of cytisinicline daily for 12 weeks. At the end of the treatment period, the researchers found that 31.8% of those treated with cytisinicline were able to maintain e-cigarette abstinence; significantly higher than the 15.1% cessation rate found in the placebo group. However, observation was made at the 16th week, the 4 weeks without treatment might have removed the difference between the groups, as the percentage of people who can cease e-cigarette use decreased to 23.4%. The researchers concluded that a larger study is needed to further elucidate the effectiveness of cytisinicline.