Exploring the Efficacy of D-Mannose in Preventing Recurrent Urinary Tract Infections
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on May 10th, 2024
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D-mannose is a naturally occurring isomer of glucose, and it can bind to bacterial fimbriae to inhibit adherence to epithelial cells. A recent publication in the Journal of the American Medical Association explored its potential in preventing uropathogen colonization in cases of recurrent urinary tract infection.
The study enrolled a total of 598 women with an average age of 58 years old who have been diagnosed with urinary tract infection and been treated with antibiotics at least 3 times within the past year or 2 times within the past 6 months. On average, the study population experienced around 4.6 episodes of infection per year which lasted for an average duration of 7.9 days. Upon enrollment into the study, the participants were randomly assigned to be treated with placebo or 2 grams of D-mannose powder every day. After 6 months, the study concluded that there was no significant difference in the amount of participants reporting at least 1 case of suspected urinary tract infection between the placebo and D-mannose group. Furthermore, D-mannose usage did not decrease the number of prescribed antibiotic courses. The researchers emphasized the need for further refinement of D-mannose before it can demonstrate clinical efficacy, consistent with existing literature.
The study enrolled a total of 598 women with an average age of 58 years old who have been diagnosed with urinary tract infection and been treated with antibiotics at least 3 times within the past year or 2 times within the past 6 months. On average, the study population experienced around 4.6 episodes of infection per year which lasted for an average duration of 7.9 days. Upon enrollment into the study, the participants were randomly assigned to be treated with placebo or 2 grams of D-mannose powder every day. After 6 months, the study concluded that there was no significant difference in the amount of participants reporting at least 1 case of suspected urinary tract infection between the placebo and D-mannose group. Furthermore, D-mannose usage did not decrease the number of prescribed antibiotic courses. The researchers emphasized the need for further refinement of D-mannose before it can demonstrate clinical efficacy, consistent with existing literature.