Adding Vancomycin to the Antimicrobial Prophylaxis Regimen of Cefazolin for patients undergone Arthroplasty
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on November 10th, 2023
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Due to the invasive nature of mechanical ventilation, it frequently increases the risk of respiratory infection that can be fatal. It is possible that antibiotic prophylaxis could be prescribed to these patients to prevent infection. Following this rationale, the French Ministry of Health had sponsored a study to assess the effectiveness of using inhaled amikacin to prevent respiratory infection in patients who were undergoing mechanical ventilation.
The study included 850 patients whose average age was 61 years old. These patients had been undergoing mechanical ventilation for at least 72 hours. The participants were randomly assigned to be treated with either amikacin or placebo. The agent was delivered in the form of nebulization once a day for 3 days. Amikacin was administered at dosage of 20 mg per kilogram of body weight. After 28 days of follow-up, the researchers concluded that amikacin inhalation helped reduce the risk of respiratory infection by 34% and ventilator-associated pneumonia by 54%. However, antibiotic prophylaxis did not reduce the length of hospitalization or the mortality rate. In terms of safety, the frequency of adverse events was not different between the two groups.
The study included 850 patients whose average age was 61 years old. These patients had been undergoing mechanical ventilation for at least 72 hours. The participants were randomly assigned to be treated with either amikacin or placebo. The agent was delivered in the form of nebulization once a day for 3 days. Amikacin was administered at dosage of 20 mg per kilogram of body weight. After 28 days of follow-up, the researchers concluded that amikacin inhalation helped reduce the risk of respiratory infection by 34% and ventilator-associated pneumonia by 54%. However, antibiotic prophylaxis did not reduce the length of hospitalization or the mortality rate. In terms of safety, the frequency of adverse events was not different between the two groups.