Possibility of using tranexamic acid to reduce the risk of death due to hemorrhage
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A. |
Posted on August 14th, 2023
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Following traumatic accidents, excessive loss of blood can lead to tissue damage and hemorrhagic shock. Thus, it is possible that preventing this blood loss before hospital admission can decrease the risk of death. Tranexamic acid is an antifibrinolytic agent that has been widely used to control hemorrhage. A study was conducted to assess the effect of prehospital tranexamic acid in preventing death after trauma.
The study included a total of 1310 patients who were admitted to emergency departments following traumatic injuries. These patients had a high risk of coagulopathy as assessed using the Coagulopathy of Severe Trauma (COAST) score. These patients were randomly assigned to be treated with either placebo or 1 gram of tranexamic acid intravenously within 3 hours after injury and before hospital admission. Afterward, the patients received an intravenous infusion of their assigned treatments. The researchers found that tranexamic acid did not reduce the risk of death or produce any clinical benefit after 28 days or 6 months after the injury.
The study included a total of 1310 patients who were admitted to emergency departments following traumatic injuries. These patients had a high risk of coagulopathy as assessed using the Coagulopathy of Severe Trauma (COAST) score. These patients were randomly assigned to be treated with either placebo or 1 gram of tranexamic acid intravenously within 3 hours after injury and before hospital admission. Afterward, the patients received an intravenous infusion of their assigned treatments. The researchers found that tranexamic acid did not reduce the risk of death or produce any clinical benefit after 28 days or 6 months after the injury.