Oral Vitamin D supplementation in infants born with low levels of serum 25-hydroxyvitamin D
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Reviewed by Dat Tien Nguyen, B.A, ScM.
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Posted on June 21st, 2023
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Maternal-fetal transfer of 25-hydroxyvitamin D (25[OH]D) is an important factor for bone development in the neonates. Thus, a low maternal level of 25[OH]D can lead to vitamin D deficiency and has a negative effect on bone health. Thus, a study examined the potential benefits of vitamin D supplementation to children whose serum 25[OH]D level is low.
The study included 139 infants whose median gestational age at birth was 39.6 months. The serum 25[OH]D level of these children is below 50 nmol/L. They were randomly assigned to receive placebo or 2 different doses of oral vitamin D3: 400 IU and 1000 IU. Supplementation was given daily for 1 year, and measurement was conducted at month 1, 3, 6, and 12 to assess the infant’s bone. Using whole-body bone mineral content, lumbar spine bone mineral density, the researchers concluded that oral vitamin D supplementation did not improve the infant bone development. a
The study included 139 infants whose median gestational age at birth was 39.6 months. The serum 25[OH]D level of these children is below 50 nmol/L. They were randomly assigned to receive placebo or 2 different doses of oral vitamin D3: 400 IU and 1000 IU. Supplementation was given daily for 1 year, and measurement was conducted at month 1, 3, 6, and 12 to assess the infant’s bone. Using whole-body bone mineral content, lumbar spine bone mineral density, the researchers concluded that oral vitamin D supplementation did not improve the infant bone development. a