Preventing obstetrical hemorrhage after cesarean delivery with tranexamic acid
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by An Duc Thien Le |
Posted on May 3rd, 2023
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Postpartum hemorrhage accounts for 27.1% of maternal death annually. Fibrinolytic activity after the placenta delivery increases the risk of hemorrhage. Tranexamic acid can improve hemostasis by preventing clot breakdown. Thus, a study was conducted to assess the effectiveness of prophylactic tranexamic acid in preventing hemorrhage in pregnant women who had cesarean delivery.
The trial included 11,000 pregnant women who are scheduled to undergo cesarean delivery. The average age of these participants was 30 years old and their average body mass index at time of delivery was approximately 35.7 - around 74% the participants have a body mass index above 30. They were randomly assigned to receive either 1 gram of tranexamic acid or placebo intravenously immediately after umbilical-cord clamping. The researchers concluded that the prophylactic usage of tranexamic acid before cesarean section does not lower the risk of maternal death or the amount of blood loss. However, the effect of tranexamic acid administration before the initiation of surgery is not known. The researchers also noted that the usage of tranexamic acid does not increase the risk of thromboembolic events.
The trial included 11,000 pregnant women who are scheduled to undergo cesarean delivery. The average age of these participants was 30 years old and their average body mass index at time of delivery was approximately 35.7 - around 74% the participants have a body mass index above 30. They were randomly assigned to receive either 1 gram of tranexamic acid or placebo intravenously immediately after umbilical-cord clamping. The researchers concluded that the prophylactic usage of tranexamic acid before cesarean section does not lower the risk of maternal death or the amount of blood loss. However, the effect of tranexamic acid administration before the initiation of surgery is not known. The researchers also noted that the usage of tranexamic acid does not increase the risk of thromboembolic events.