Using hydrochlorothiazide diuretics to prevent nephrolithiasis
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Reviewed by Dat Tien Nguyen, B.A, ScM.
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Posted on March 8th, 2023
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Thiazide diuretics, such as hydrochlorothiazide, are frequently given to prevent recurrent nephrolithiasis. However, there is a lack of evidence on the effectiveness of this treatment and what the most appropriate dose would be. Thus, a study, funded by the Swiss National Science Foundation, was conducted to investigate the clinical effect of various hydrochlorothiazide doses in preventing kidney stone formation.
The study included 416 adults, whose median age is 49 years old, with at least two episodes of calcium-containing kidney stones in the past ten years. They were randomly assigned to receive either placebo or 1 capsule of hydrochlorothiazide once a day at 3 different doses: 12.5 mg, 25 mg, and 50 mg. At the end of the 3 year surveillance period, the study found that there was no significant difference in the frequency of nephrolithiasis between the different hydrochlorothiazide doses and placebo.
The study included 416 adults, whose median age is 49 years old, with at least two episodes of calcium-containing kidney stones in the past ten years. They were randomly assigned to receive either placebo or 1 capsule of hydrochlorothiazide once a day at 3 different doses: 12.5 mg, 25 mg, and 50 mg. At the end of the 3 year surveillance period, the study found that there was no significant difference in the frequency of nephrolithiasis between the different hydrochlorothiazide doses and placebo.