Early usage of oseltamivir helps improve the clinical outcomes of children hospitalized due to Influenza infection
|
Reviewed by Dat Tien Nguyen, B.A, ScM.
|
Posted on September 26th, 2022
|
According to the Global Burden of Disease (GBD) study in 2019, respiratory infection is the third leading cause of death for children younger than 5 years old in Vietnam. Thus, it is important to update and improve our current standard of care for children who have been infected with diseases like Influenza. A recent study published in the journal JAMA Pediatric reported that oseltamivir helps improve the outcome of children hospitalized due to Influenza.
The study retrospectively looked at the health data of 55,799 childrens, with a mean age of 3.6 years old, that were admitted due to influenza between 2007 and 2020. The study compared the health outcome of children who were treated with oseltamivir right after hospitalization to those who did not receive oseltamivir. Early usage of the antiviral help shorten the length of hospital stay, reduce the 1-week hospital readmission rate by 28% and reduce the risk of ICU admission by 59%.
Oseltamivir is well-tolerated by pediatric patients, 36.1% reported adverse events that are relatively mild, such as vomiting and diarrhea. Thus, the American Academy of Pediatrics had recommended its usage to manage hospitalized children with Influenza. Similar instructions can potentially be included into the current clinical guideline to reduce the rate of infant mortality in Vietnam.
The study retrospectively looked at the health data of 55,799 childrens, with a mean age of 3.6 years old, that were admitted due to influenza between 2007 and 2020. The study compared the health outcome of children who were treated with oseltamivir right after hospitalization to those who did not receive oseltamivir. Early usage of the antiviral help shorten the length of hospital stay, reduce the 1-week hospital readmission rate by 28% and reduce the risk of ICU admission by 59%.
Oseltamivir is well-tolerated by pediatric patients, 36.1% reported adverse events that are relatively mild, such as vomiting and diarrhea. Thus, the American Academy of Pediatrics had recommended its usage to manage hospitalized children with Influenza. Similar instructions can potentially be included into the current clinical guideline to reduce the rate of infant mortality in Vietnam.