The effect of Vitamin D3 supplement on the risk of bone fracture in older adults
Reviewed by Dat Tien Nguyen, B.A, ScM. Posted on July 25th, 2022
Vitamin D is frequently taken as a supplement by many Vietnamese in order to manage and prevent many age-related musculoskeletal conditions and injury such as osteoporosis and bone fracture. However, a study recently published in the New England Journal of Medicine reported that Vitamin D3 supplement has no benefit in reducing the risk of bone fracture in older adults.
The randomized control trial was conducted by Dr. Meryl S. LeBoff, MD and it is a part of the Vitamin D and Omega-3 Trial (VITAL). The trial included 25,871 participants, 50.6% of them are female, and the median age is 67.1 +/- 7.1 years. The participants were followed up for a median period of 5.3 years. Half of the study population is assigned to the intervention group that was given Vitamin D3 (2,000 IU) supplement daily; whereas, the control group received a placebo. The study found that there is no significant difference in the risk of total fracture, nonvertebral fracture, and hip fracture between those who took the supplement and placebo.
This finding is very congruent with the current literature. As a result, since 2018, the United States Preventive Services Task Force (USPSTF) had recommended against the usage of Vitamin D3 by postmenopause women to prevent bone fracture, citing inconsistent evidence.
However, in a http://benhvien103.vn/wp-content/uploads/8._HDDT-Co-Xuong-Khop.pdf, patients are recommended to take Vitamin D3 (800 - 1,000 IU) supplement daily to treat osteoporosis and improve the general wellness of the skeletal system. With these new findings refuting the benefit of Vitamin D3 on bone fracture, it might be time for the national health agency to reconsider their clinical guidelines.
The randomized control trial was conducted by Dr. Meryl S. LeBoff, MD and it is a part of the Vitamin D and Omega-3 Trial (VITAL). The trial included 25,871 participants, 50.6% of them are female, and the median age is 67.1 +/- 7.1 years. The participants were followed up for a median period of 5.3 years. Half of the study population is assigned to the intervention group that was given Vitamin D3 (2,000 IU) supplement daily; whereas, the control group received a placebo. The study found that there is no significant difference in the risk of total fracture, nonvertebral fracture, and hip fracture between those who took the supplement and placebo.
This finding is very congruent with the current literature. As a result, since 2018, the United States Preventive Services Task Force (USPSTF) had recommended against the usage of Vitamin D3 by postmenopause women to prevent bone fracture, citing inconsistent evidence.
However, in a http://benhvien103.vn/wp-content/uploads/8._HDDT-Co-Xuong-Khop.pdf, patients are recommended to take Vitamin D3 (800 - 1,000 IU) supplement daily to treat osteoporosis and improve the general wellness of the skeletal system. With these new findings refuting the benefit of Vitamin D3 on bone fracture, it might be time for the national health agency to reconsider their clinical guidelines.