Pregnancy Complications and Long-Term Risk of Multiple Sclerosis in Offspring
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on February 9th, 2026
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Multiple sclerosis is an autoimmune disease with neurological symptoms caused by the immune attack on myelin sheath insulating neurons. It is known that adverse pregnancy outcomes such as preterm birth, hypertensive disorders of pregnancy, etc. can alter immune development. Following this logic, a study was conducted to explore the effect of abnormalities during pregnancy on the risk of developing multiple sclerosis later in life.
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Treating Episodic Migraine in Children and Adolescents with Fremanezumab
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on February 4th, 2026
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Recent epidemiological studies have found that 1 in 10 children and adolescents experience episodic migraine. This disorder detrimentally impacted the life and wellbeing of the affected children. Current treatment for children had limited efficacy and severe side effects; thus, a study was conducted, with funding from Teva Pharmaceuticals, to assess the usage of fremanezumab, an approved medication for adults, to manage migraine in children.
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Treating Tuberculosis Meningitis with High-Dose Oral Rifampin
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on January 30th, 2026
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Treating tuberculosis meningitis is challenging due to the complicated medical regimen, the increased prevalence of resistance, and the medication inability to penetrate into the cerebrospinal fluid. This resulted in a lower clinical outcome and a high mortality rate in patients with HIV comorbidity. A study funded by the U.K. Medical Research Council, was conducted to assess the usage of a high-dose rifampin regimen to treat tuberculosis meningitis.
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Using Valacyclovir to Treat Early Symptomatic Alzheimer’s Disease
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on January 16th, 2026
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During the latent stage after initial site infection with herpes simplex virus HSV-1 and HSV-2, the virus can infiltrate trigeminal ganglion and migrate to the brain via retrograde axonal transport. In animal study, HSV can infect neuronal and glial cells causing accumulation of amyloid β-protein, and tau protein phosphorylation, a hallmark of Alzheimer’s disease. Moreover, a postmortem study found that 90% of patients with Alzheimer’s disease had detectable HSV-1 DNA in the amyloid plaques. With funding from the United States National Institutes on Aging, a study was commissioned to examine the effectiveness of valacyclovir in treating symptomatic Alzheimer’s disease.
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Tirofiban as an Adjunct to Thrombolysis in Ischemic Stroke
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on October 13th, 2025
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For ischemic stroke, intravenous thrombolysis is recommended within 4.5 hours of onset. However, even with timely treatment, more than half of patients fail to regain full function. To increase treatment efficacy, the Chinese government funded a study to evaluate whether tirofiban could improve recovery outcomes when added to standard thrombolysis.
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Examines Darbepoetin for Neurodevelopment in Preterm Infants
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on September 10th, 2025
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Preterm infants face a markedly higher risk of neurodevelopmental complications. Previous research has suggested that stimulating red blood cell production with erythropoietin may have neuroprotective effects. To further investigate this potential, a study recently published in the Journal of American Medical Association evaluated whether darbepoetin could improve neurodevelopmental outcomes in preterm infants.
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Tenecteplase Thrombolysis before Thrombectomy in Patients with Ischemic Stroke
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on July 30th, 2025
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Intravenous thrombolysis before endovascular thrombectomy is associated with benefit in the form of enhancing perfusion but with the increased risk of hemorrhage. Several previous studies had found inconsistent results, but most of the studies were conducted with alteplase. With funding from the Chinese government, a study was conducted to assess the usage of tenecteplase before thrombectomy for stroke patients.
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Anti-CD19 Inebilizumab in Managing Myasthenia Gravis
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on July 7th, 2025
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Myasthenia gravis is an autoimmune disease in which B cells produce antibodies targeting the acetylcholine receptor at the neuromuscular junction. The disease can be managed by anti-inflammatory glucocorticoid and cholinesterase inhibitors to increase the signal duration at the neuromuscular junction. Targeting the B-cells producing autoantibody is another option with rituximab targeting the CD20 marker on B-cells. Inebilizumab is another viable option that targets another marker on B-cells. Amgen had sponsored a study to evaluate its effectiveness in managing myasthenia gravis.
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Impact of Long-Term Tiotropium Usage on Dementia Risk
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on June 13th, 2025
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Medications that interfere with acetylcholine signaling have been linked to cognitive decline. Long-acting antimuscarinic agents like tiotropium, commonly prescribed for chronic obstructive pulmonary disease (COPD), have known anticholinergic effects, but their impact on neurological function remains unclear. Previous studies on this topic have been limited by poor design. To address this gap, a study funded by the Brain Canada Foundation examined whether tiotropium use is associated with an increased risk of developing dementia.
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Oral Orexin Agonist Oveporexton Shows Promise for Narcolepsy Without Liver Toxicity
Topic: NEUROLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on June 11th, 2025
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The loss of orexin-producing neurons in the hypothalamus is the primary driver of narcolepsy, particularly type 1. While existing treatments focus on alleviating symptoms—such as promoting daytime wakefulness and reducing cataplexy—they do not target the underlying orexin deficiency. Previous attempts to develop orexin receptor agonists have been hampered by the need for intravenous delivery and concerns over liver toxicity. With funding from Takeda, a new study explored the use of oveporexton, a blood-brain barrier–permeable, orally administered orexin agonist, for the treatment of narcolepsy.
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Tolebrutinib and Teriflunomide Yield Similar Outcomes in Relapsing Multiple Sclerosis
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on June 9th, 2025
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Current therapies for multiple sclerosis (MS) primarily aim to control the inflammation that leads to white matter lesions. Among the more than 20 approved treatments, anti-CD20 monoclonal antibodies have proven effective in reducing lesion formation and preventing relapses. However, these therapies have shown limited success in halting the progression of disability. To explore alternative approaches, Sanofi sponsored a series of studies to evaluate the effectiveness of tolebrutinib in preventing relapses in patients with MS.
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High-Dose Vitamin D Supplementation to Manage and Prevent Multiple Sclerosis
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on April 11th, 2025
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In patients with multiple sclerosis, low levels of vitamin D are linked to an increased risk of relapse, a greater disease burden, and more brain lesions. Vitamin D modulates the immune system by reducing lymphocyte differentiation and limiting the migration of immune cells across the blood-brain barrier. Based on this hypothesis, a study funded by the French Ministry of Health was conducted to assess the potential of vitamin D in managing multiple sclerosis and preventing relapses.
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Potential Usage of Acetylcholine Muscarinic 1 Receptor Agonist to Manage Parkinson Disease
Topic: NEUROLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on April 2nd, 2025
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Acetylcholine deficiency is linked to Parkinson’s disease and has been associated with increased stride time variability and a higher risk of falls. Normally, acetylcholine is released into the synaptic cleft to activate neighboring neurons, and its signaling is terminated by acetylcholinesterase, which degrades the neurotransmitter. However, acetylcholinesterase inhibitors have not reduced the disease burden and often lead to unacceptable side effects. To address this, a study funded by Takeda Pharmaceutical was conducted to assess TAK-071, a novel muscarinic acetylcholine 1 receptor agonist, for managing Parkinson’s disease.
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Assessing the Impact of Maternal SARS-CoV-2 Infection and COVID-19 Vaccination on Early Childhood Development
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on March 26th, 2025
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Currently, there is limited agreement on how maternal SARS-CoV-2 infection impacts early childhood development. Similarly, the effect of maternal COVID-19 vaccination on a child's early development remains unclear. To address these gaps in understanding, the United Kingdom’s Economic and Social Research Council sponsored a population-level study to evaluate the impact of both maternal infection and COVID-19 vaccination on early childhood development.
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The Effect of Deferiprone on Iron Level in the Brain and Cognitive Decline in Alzheimer’s Disease
Topic: NEUROLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on March 3rd, 2025
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Previous neurological research indicates that elevated iron accumulation in the brain is linked to neurodegeneration in patients with Alzheimer’s disease, potentially due to iron’s role in promoting cell death through ferroptosis. Supported by funding from ApoPharma, a study was conducted to evaluate the use of deferiprone, an iron chelator, for managing neuropsychological symptoms in Alzheimer’s disease.
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Vitamin K2 Supplementation as a Potential Treatment for Nocturnal Leg Cramps
Topic: NEUROLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on November 13th, 2024
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Nocturnal leg cramps are common among adults and can sometimes lead to insomnia and distress in rare severe cases. Currently, there are no safe and effective treatments: magnesium and calcium channel blockers have shown limited efficacy, and quinine poses toxicity risks. Previous research found that vitamin K2 supplementation reduced the frequency, severity, and duration of muscle cramps in dialysis patients. Based on these findings, a study was conducted to explore the potential of vitamin K2 supplementation for managing nocturnal leg cramps.
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Lithium Aspartate Ineffective in Reducing Post-COVID-19 Fatigue and Cognitive Dysfunction at Standard Doses
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Reviewed & translated by Dat Tien Nguyen, B.A, ScM.
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Posted on November 1st, 2024
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Lithium is a widely used treatment for bipolar disorder, known for its neuroprotective effects through the suppression of inflammation mediated by astrocytes and microglia. Positron emission tomography (PET) scans of patients suffering from post-COVID-19 fatigue and cognitive dysfunction have revealed persistent brain inflammation. In response, the National Institutes of Health (NIH) funded a study to investigate the potential of lithium in managing neurological complications associated with post-COVID-19 conditions.
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Impact of Adjunctive Argatroban and Eptifibatide on Post-Stroke Outcomes
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Reviewed & translated by Dat Tien Nguyen, B.A, ScM.
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Posted on Octber 21st, 2024
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Treating ischemic stroke solely with intravenous thrombolytic agents results in approximately 30% recanalization of the occlusion. Argatroban, an arginine derivative, functions as an anticoagulant by binding to thrombin and inhibiting fibrin formation, while eptifibatide reduces platelet aggregation by blocking glycoprotein receptors. To evaluate the potential benefits of adding either argatroban or eptifibatide to standard thrombolytic therapy in reducing ischemic stroke complications, a study was sponsored by the National Institute of Neurological Disorders and Stroke.
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Targeting Pituitary Adenylate Cyclase-Activating Polypeptide with Lu AG09222 Antibody to Prevent Migraine
Topic: NEUROLOGY
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Reviewed & translated by Dat Tien Nguyen, B.A, ScM.
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Posted on Octber 18th, 2024
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Migraine is a prevalent condition that can severely impact an individual's quality of life. Preventative treatments like propranolol and topiramate have often proven either ineffective or associated with significant side effects. Previous research has demonstrated that pituitary adenylate cyclase-activating polypeptide (PACAP) can induce migraine attacks in patients. Consequently, a study was conducted in Denmark, with funding from the pharmaceutical company Lundbeck, to explore the potential of Lu AG09222, a PACAP-targeting antibody, as a treatment for managing migraines.
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Suvorexant in the Prevention of Delirium in Elderly Hospitalized Patients
Topic: NEUROLOGY
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Reviewed & translated by Dat Tien Nguyen, B.A, ScM.
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Posted on Octber 14th, 2024
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Delirium presents a significant challenge in hospital care, particularly for older patients, where delirium episodes can lead to serious complications. Insomnia is a key factor that exacerbates delirium, suggesting that sleep-promoting treatments may help manage the condition. To explore this, a recent study, funded by Merck, evaluated the potential of suvorexant, an orexin receptor antagonist, to reduce the risk of delirium in hospitalized patients.
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Impact of Omega-3 Supplementation on White Matter Lesions and Neuronal Integrity
Topic: NEUROLOGY
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Reviewed & translated by Dat Tien Nguyen, B.A, ScM.
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Posted on Octber 4th, 2024
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Individuals with white matter lesions are at an elevated risk for dementia, cognitive decline, and Alzheimer’s disease. Previous research has indicated that a diet high in omega-3 fatty acids, particularly EPA and DHA, can help reduce inflammation and the progression of white matter lesions. To explore whether omega-3 supplementation could prevent white matter loss and mitigate the risk of neuronal integrity breakdown, a study was conducted.
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Evaluating the Impact of Fecal Microbiota Transplantation on Parkinson’s Disease
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Reviewed & translated by Dat Tien Nguyen, B.A, ScM.
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Posted on September 6th, 2024
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Gut microbiota dysbiosis has been observed in patients with premotor symptoms of Parkinson’s disease and may accelerate disease progression. Previous animal studies have indicated that fecal microbiota transplantation (FMT) could offer neuroprotective benefits in Parkinson’s. A recent study published in the Journal of the American Medical Association investigated whether FMT could improve outcomes in Parkinson’s disease.
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Comparative Efficacy and Safety of Reteplase Versus Alteplase in Ischemic Stroke
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Reviewed & translated by Dat Tien Nguyen, B.A, ScM.
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Posted on August 19th, 2024
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Thrombolytic agents like tenecteplase and alteplase are standard treatments for ischemic stroke. Reteplase, another plasminogen activator known for its double-bolus administration, has been approved in many countries for treating myocardial infarction. A study sponsored by China Resources Angde Biotech Pharma compared the effectiveness of reteplase with alteplase in treating ischemic stroke.
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Efficacy of Tenecteplase Administered Between 4.5 and 24 Hours Post-Ischemic Stroke Onset
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Reviewed & translated by Dat Tien Nguyen, B.A, ScM.
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Posted on August 14th, 2024
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Thrombolytic therapy with plasminogen activators such as alteplase and tenecteplase is recommended within 4.5 hours of ischemic stroke symptom onset. However, many ischemic stroke cases reach the hospital after this window. While alteplase remains highly effective when administered within the first 9 hours, the effectiveness of tenecteplase beyond 4.5 hours is less understood. Therefore, the National Natural Science Foundation of China funded a study to evaluate the efficacy of tenecteplase when administered between 4.5 and 24 hours after ischemic stroke onset.
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Investigating the Effect of Early Iron Supplementation in the Neurodevelopment of Breastfed Infants
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on June 5th, 2024
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Infantile iron deficiency is a common global problem, which is more severe in resource-limited communities. Anemia caused by iron deficiency can potentially interfere with neurodevelopment and cause cognitive impairment and behavioral problems. Since the iron content of breast milk is low, there is a debate on the necessity of iron supplementation. To fill this gap in knowledge, a study was conducted in Poland and Sweden to investigate the effect of daily iron supplementation on early cognitive development.
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Investigating the efficacy of Alectinib, an ALK inhibitor, in ALK-Positive Non-Small-Cell Lung Cancer
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on April 29th, 2024
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Approximately 5% of all cases of non-small-cell lung cancer (NSCLC) exhibit rearrangement to the anaplastic lymphoma kinase (ALK) gene. This specific subset of NSCLC can be treated with platinum-based combination chemotherapy; however, this regimen has modest improvements to the survival rate and it has a relatively high risk of disease recurrence. Alectinib is an ALK inhibitor, and a study has been conducted to assess its efficacy in managing ALK-positive NSCLC.
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Assessing the Efficacy of Lixisenatide in Managing Parkinson’s Disease Progression
Topic: NEUROLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on April 22nd, 2024
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The majority of current biological interventions for Parkinson’s disease focus on dopamine replacement therapy, as dopamine deficiency is a central feature of the condition. However, recent research has identified a heightened risk of Parkinson's in individuals with type 2 diabetes. Interestingly, individuals treated with glucagon-like peptide 1 receptor (GLP-1R) agonists appear to have the lowest risk of developing Parkinson's. In response to these findings, the French Ministry of Health initiated a study to investigate the potential of using Lixisenatide, a GLP-1R agonist commonly prescribed for type 2 diabetes, as a treatment for Parkinson’s disease.
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Investigating Antiseizure Medication Use During Pregnancy and Autism Risk
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on April 17th, 2024
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During pregnancy, the administration of medication can significantly influence fetal development. Expectant mothers with epilepsy often require antiseizure medication throughout their pregnancy to manage their condition. Numerous studies have indicated that certain medications like topiramate, valproate, and lamotrigine may have teratogenic effects, potentially resulting in adverse neurodevelopmental outcomes. Consequently, the United States National Institute of Mental Health funded a comprehensive study to investigate the correlation between maternal use of antiseizure medication and the risk of autism spectrum disorder in their children.
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Assessing the Efficacy of Frexalimab in Managing Multiple Sclerosis
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on March 29th, 2024
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The interaction between CD40 and CD40L plays a pivotal role in immune system activation. In individuals with multiple sclerosis, elevated CD40L expression fosters a robust T-lymphocyte response, contributing to disease progression. Consequently, Frexalimab, an antibody designed to bind to CD40L and impede this interaction, holds promise in mitigating disease severity. A recent study evaluating the efficacy of Frexalimab in managing multiple sclerosis has been published in the New England Journal of Medicine.
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Comparing Donor Milk and Preterm Formula Effects on Neurodevelopment in Preterm Infants
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Reviewed & translated by Dat Tien Nguyen, B.A, ScM.
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Posted on March 15th, 2024
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Preterm infants face elevated risks of sepsis, enterocolitis, and bronchopulmonary dysplasia, conditions that may contribute to neurodevelopmental issues. Maternal milk has been associated with mitigating these risks and promoting typical neurodevelopment. Consequently, a study was undertaken to evaluate the impact of donor milk versus preterm formula on the neurodevelopment of preterm infants.
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Using beta-amyloid specific antibody, Gantenerumab, to slow down cognitive decline associated with Alzheimer’s disease
Topic: NEUROLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on December 1st, 2023
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Previous studies had shown that beta-amyloid specific antibodies can be utilized to halt the cognitive decline associated with Alzheimer’s disease. However, the degree of clinical benefit is linked to the antibody’s ability of binding and removing the beta-amyloid. Gantenerumab is an antibody that has been proven to have a high affinity to beta-amyloid. Recently, a paper was published in the New England Journal of Medicine reporting the effectiveness of Gantenerumab in managing Alzheimer’s development.
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Alleviating head tremor symptoms with botulinum toxin
Topic: NEUROLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on November 29th, 2023
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Head tremor is a common movement disorder with a prevalence of approximately 1%. The disease is more common with old age: the disease prevalence increases to 5% in people above 65 years old. Without an effective treatment, the French Ministry of Health had funded a study to examine the possibility of using Botulinum toxin in managing head tremor.
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Solanezumab's Impact on Beta-Amyloid and Cognitive Decline in Alzheimer's Disease Management
Topic: NEUROLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on October 20th, 2023
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The accumulation of defective beta-amyloid in the brain of patients with Alzheimer’s disease interferes with neurotransmission and leads to the clinical manifestations associated with the condition. Thus, clearance of these beta-amyloid plaques can potentially revert the symptoms. Thus, the National Institute on Aging had sponsored a study to investigate the effect of solanezumab in managing Alzheimer’s disease.
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Assessing Dabrafenib and Trametinib Combination Therapy for Pediatric Glioma with BRAF V600E Mutation
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on October 16th, 2023
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Glioma is the most common central nervous system tumor in pediatric patients. While resection and chemotherapy have improved the 5-year survival rate to 95%, relapses still occur, necessitating the development of new therapies. About 20% of pediatric low-grade gliomas feature the BRAF V600E mutation. Consequently, a study was conducted to explore whether Dabrafenib, a selective BRAF V600E inhibitor, and Trametinib could offer similar benefits to pediatric patients as they have for adults.
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Using long-term antibiotic prophylaxis to prevent urinary tract infection in pediatric patients with grade III, IV, and V vesicoureteral reflux
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on October 4th, 2023
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In children diagnosed with moderate-to-severe vesicoureteral reflux, continuous antibiotic therapy is a current practice aimed at lowering the risk of urinary tract infections, which can potentially progress to pyelonephritis and result in kidney scarring. Nevertheless, the prolonged use of antibiotics has the potential to disturb the child's microbiome and contribute to the emergence of multidrug-resistant bacteria. As a result, a study was conducted to assess the advantages and potential risks associated with antibiotic prophylaxis in children diagnosed with grade III, IV, and V vesicoureteral reflux.
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Inflammation in the brain linked to COVID-19 may lead to depressive symptoms and hinder cognitive abilities
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on September 25th, 2023
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Previous studies had observed depression, cognitive impairment, and anhedonia to be post-COVID-19 sequelae; however, the exact mechanism behind this association is not known. Thus, a study, recently published to the Journal of the American Medical Association, had investigated the impact of SARS-CoV-2 infection on the brain, especially compartments that can be associated with mood disorder and mental faculty.
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Relieving postoperative pain using a novel NaV1.8 voltage-gated sodium channel inhibitor
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Reviewed by Nhi Phuong Quynh Le, B.A
Translated by Dat Tien Nguyen, B.A, ScM. |
Posted on September 15th, 2023
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NaV1.8 voltage-gated sodium channel is responsible for transmitting nociceptive signals in the peripheral nervous system. Previous studies have shown that VX-548 can selectively inhibit the NaV1.8 channel in vitro and reduce acute pain in vivo. Thus, researchers conducted a study to examine the effectiveness and safety of using oral VX-548 in patients who are experiencing postoperative acute pain.
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The effect of low-saturated fat, heart-healthy diet on cognitive decline and the risk of Alzheimer’s dementia
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on September 13th, 2023
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Although there have been many therapies approved to treat Alzheimer’s disease, there has been little progress in investigating the optimal prevention method. Since the Western high-fat diet had been associated with increased risk of many chronic diseases, and the Mediterranean diet had been shown to be beneficial, a study was conducted to investigate the effect of dietary change on the risk of Alzheimer’s.
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Using Vorasidenib to treat low grade glioma brain tumor with isocitrate dehydrogenase mutation
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on September 11th, 2023
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Most malignant brain tumors in adults are gliomas, and nearly all of them have mutations to the isocitrate dehydrogenase (IDH) gene. These mutated IDH lead to the accumulation of 2-hydroxyglutarate that can disrupt the process of DNA hydroxymethylation and gene expression in glioma tissue. Vorasidenib is a molecule that can cross the blood-brain barrier and inhibit the mutated version of IDH; thus, a study was conducted to assess its effect on malignant glioma tumor tissues.
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Using the anti-inflammatory effect of dexamethasone to treat chronic subdural hematoma instead of burr-hole craniostomy
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Reviewed by translated by Dat Tien Nguyen, B.A, ScM.
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Posted on July 17th, 2023
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Over the past decades, the prevalence of chronic subdural hematoma has been increasing in many developed nations. This can be explained by the aging of the population and the usage of anticoagulants to treat cardiovascular conditions. Burr-hole craniostomy is needed to drain the hematoma; this is an effective procedure but there is an increased risk of death. It is hypothesized that the inflammatory reaction exacerbates the hematoma by accumulating liquid and increasing clotting incidence. Thus, a study was conducted to investigate the potential usage of dexamethasone in treating chronic subdural hematoma.
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Assessing the effectiveness of the Meningococcal ACWYX Conjugate Vaccine in children and young adults
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Reviewed & translated by An Duc Thien Le
Edited by Dat Tien Nguyen, B.A, ScM. |
Posted on July 5th, 2023
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Among the six serogroups of meningococcal (A, B, C, W, X, Y), serogroup A was identified as the primary cause of the majority of cases. However, thanks to the extensive vaccination program involving the MenACWY-D vaccine, the impact of serogroup A was effectively controlled and managed. Recently, the incidence rate is rising again due to other serogroups especially serogroup X as it is not included in the current four quadrivalent meningococcal conjugate MenACWY-D vaccine. Thus, a study was conducted to investigate the effectiveness and safety of novel pentavalent meningococcal ACWYX conjugate vaccine (NmCV-5).
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Treating cryptococcal meningitis with liposomal amphotericin B
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by An Duc Thien Le |
Posted on April 26th, 2023
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Due to their immunodeficiency, HIV infected patients are more susceptible to opportunistic infections. Cryptococcal meningitis is the second leading cause of HIV-related death. The high mortality is due to either the ineffectiveness of the fluconazole or the high toxicity of the long-course amphotericin B deoxycholate. Liposomal amphotericin B can be given at a higher dose due to its lower rate of side effects. Compounded with its ability to penetrate the blood-brain barrier and long half-life, a study had been conducted to examine the usage of Liposomal amphotericin B antifungal combination therapy in treating cryptococcal meningitis.
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Using GD2-CART01 cells to treat neuroblastoma in pediatric patients
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Reviewed by Dat Tien Nguyen, B.A, ScM.
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Posted on April 17th, 2023
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Neuroblastoma is one of the most common causes of cancer death in pediatric patients. Disialoganglioside GD2 is highly expressed by neuroblastoma cells; thus, monoclonal antibody treatment has yielded positive outcomes. T-cells with chimeric antigen receptors, also known as CAR-T cells, is the novel method of cancer treatment; the T-cells were engineered to express receptors that can bind to specific cellular antigen and induce death in the expressing cell. Thus, the Italian Medicines Agency had sponsored a study to investigate the effect of the GD2-CART01 CAR-T cells in treating neuroblastoma
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Experimental ultrasound ablation of the globus pallidus to manage Parkison’s disease
Topic: NEUROLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
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Posted on February 27th, 2023
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Recently, deep brain stimulation has been utilized to treat Parkinson’s disease. However, this procedure requires open brain surgery and frequent visits to the hospital for maintenance of the device. Thus, a less invasive method and requires less upkeep would be more efficient. A recent study sponsored by the medical device company Insightec had published their findings on the effectiveness of using ultrasound ablation to manage Parkinson’s.
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The effectiveness of 4CMenB vaccine in preventing invasive meningococcal disease in children
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Reviewed by Dat Tien Nguyen, B.A, ScM.
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Posted on February 17th, 2023
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Neisseria meningitidis is the major bacterial cause behind invasive meningitis in children. The four-component protein-based meningococcal B vaccine (4CMenB) is sold by the pharmaceutical company GlaxoSmithKline under the brand name Bexsero and has been widely used worldwide. A recent study published in the New England Journal of Medicine had published their finding on the effectiveness of the 4CMenB vaccine on preventing infection in young children.
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Potential usage of anti-amyloid beta antibody to prevent Alzheimer’s progression
Topic: NEUROLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
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Posted on February 8th, 2023
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Alzheimer’s is caused by the over-accumulation of aggregated amyloid beta protein inside the brain. These amyloid plaque can interfere with the normal function of neurons and lead to dementia. Lecanemab is an antibody that can bind to these amyloid beta proteins which can result in the clearance of these clumps. A recent study had examined the effectiveness of Lecanemab in preventing the progression of Alzheimer’s disease
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