Targeting Apolipoprotein C-III with Olezarsen to Reduce Triglycerides and Prevent Acute Pancreatitis
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on March 6th, 2026
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Severe hypertriglyceridemia is a well-established risk factor for acute pancreatitis, a condition associated with substantial morbidity and mortality. Consequently, therapies that lower serum triglyceride levels, such as fibrates, are commonly used to reduce pancreatic complications. A recent study published in the New England Journal of Medicine evaluated the efficacy and safety of olezarsen, a novel agent targeting apolipoprotein C-III, in lowering triglyceride levels and preventing pancreatitis.
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Managing Chronic Hepatitis D Infection with Tobevibart & Elebsiran
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on March 4th, 2026
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While not as frequently discussed, Hepatitis D viral infection is a severe chronic condition that can significantly increase the risk of cirrhosis and eventual hepatocellular carcinoma. The infection can be managed with bulevirtide. However, bulevirtide usage is troublesome due to the need of daily subcutaneous injections. Plus, patients have a high risk of relapse of treatment stop. Due to a need for a new therapy, a study was performed to explore the usage of tobevibart plus elebsiran to manage hepatitis D infection.
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Decade-Long Clinical Outcome & Safety of Nivolumab Treatment in Advanced Melanoma
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on March 2nd, 2026
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After extensive testing, it has been found that nivolumab is an effective treatment for advanced-stage melanoma. When compared with other immunotherapy, nivolumab had also proven to be superior. A long-term surveillance study on the clinical outcome of nivolumab on melanoma had recently been published in the New England Journal of Medicine.
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Treating Non-Small Cell Lung Cancer with mutated EGFR using Sacituzumab Tirumotecan
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on February 13th, 2026
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Tumors of patients with non-small cell lung cancer express a high level of receptor for epidermal growth factor (EGFR). Because these receptors are important for tumor proliferation, targeting them with EGFR tyrosine kinase inhibitors (EGFR-TKI) has been an effective strategy to manage the cancer. However, mutation to EGFR can happen, and this leads to resistance against the EGFR-TKI. In these cases, a study was conducted to explore the usage of sacituzumab tirumotecan as an alternative means of treatment.
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RSV Vaccine Effectiveness at Reducing Hospitalization in the Elderly
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on February 11th, 2026
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Respiratory syncytial virus (RSV) infection has become more prevalent in the recent years post pandemic. For elderly patients, these RSV infections can lead to fatal outcomes. There exists a vaccine to prevent RSV infection, and it has been proven to be highly effective at preventing RSV-related lower respiratory tract. To further explore the benefit of this vaccine, a study was conducted to investigate its ability to prevent hospitalization in the elderly.
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Pregnancy Complications and Long-Term Risk of Multiple Sclerosis in Offspring
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on February 9th, 2026
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Multiple sclerosis is an autoimmune disease with neurological symptoms caused by the immune attack on myelin sheath insulating neurons. It is known that adverse pregnancy outcomes such as preterm birth, hypertensive disorders of pregnancy, etc. can alter immune development. Following this logic, a study was conducted to explore the effect of abnormalities during pregnancy on the risk of developing multiple sclerosis later in life.
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Manage LDL Cholesterol Level with Evolocumab to Prevent Severe Cardiovascular Outcome
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on February 6th, 2026
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Elevated levels of low-density lipoprotein (LDL) cholesterol promote plaque formation along the vascular endothelium, leading to luminal narrowing and impaired blood flow. This process substantially increases the risk of atherosclerotic cardiovascular events, including myocardial infarction and ischemic stroke. With funding from Amgen, a large clinical study was conducted to evaluate the effectiveness of evolocumab in preventing major cardiovascular outcomes.
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Treating Episodic Migraine in Children and Adolescents with Fremanezumab
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on February 4th, 2026
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Recent epidemiological studies have found that 1 in 10 children and adolescents experience episodic migraine. This disorder detrimentally impacted the life and wellbeing of the affected children. Current treatment for children had limited efficacy and severe side effects; thus, a study was conducted, with funding from Teva Pharmaceuticals, to assess the usage of fremanezumab, an approved medication for adults, to manage migraine in children.
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Osimertinib plus Chemotherapy for Non-Small Cell Lung Cancer with Mutated EGFR
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on February 2nd, 2026
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Osimertinib is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. Prior studies have demonstrated that osimertinib is more effective in treating non–small cell lung cancer than earlier-generation EGFR inhibitors and platinum-based chemotherapy. Separately, recent evidence has shown that combining platinum-based chemotherapy with the second-generation EGFR inhibitor gefitinib leads to improved clinical outcomes compared with gefitinib alone. Building on these findings, a study funded by AstraZeneca was conducted to evaluate whether adding platinum-based chemotherapy to osimertinib could further improve outcomes.
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Treating Tuberculosis Meningitis with High-Dose Oral Rifampin
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on January 30th, 2026
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Treating tuberculosis meningitis is challenging due to the complicated medical regimen, the increased prevalence of resistance, and the medication inability to penetrate into the cerebrospinal fluid. This resulted in a lower clinical outcome and a high mortality rate in patients with HIV comorbidity. A study funded by the U.K. Medical Research Council, was conducted to assess the usage of a high-dose rifampin regimen to treat tuberculosis meningitis.
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Usage of One HPV Vaccine Dose in Resource-Limited Settings
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on January 28th, 2026
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Human papilloma virus (HPV) infection is one of the most common etiological causes of cervical cancer. Vaccination had been successful at preventing infection and lowering the disease risk. However, worldwide vaccine coverage is low; thus, the burden of cervical cancer is majorly borne by underdeveloped nations. With funding from the National Cancer Institute, a study was conducted to assess the preventative capability of a one-dose HPV vaccine schedule.
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Tirzepatide versus Dulaglutide in Preventing Cardiovascular Disease
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on January 26th, 2026
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Usage of GLP-1 agonists had become very common as a means to control body weight, manage diabetes, and prevent other obesity-related health complications. Some of these complications are cardiovascular events such as myocardial infarction and stroke. With funding from Eli Lilly, a study was conducted to compare tirzepatide to dulaglutide in preventing cardiovascular disease.
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Atezolizumab for Patients with Detectable Circulating Tumor DNA Following Radical Cystectomy for Muscle-Invasive Bladder Cancer
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on January 23rd, 2026
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Radical cystectomy is the standard first-line treatment for patients diagnosed with muscle-invasive bladder cancer; however disease recurrence still happens in 50% of the cases. Adjuvant therapy can be conducted, but there is a risk of unnecessary treatment and side effects if there is no residual disease. Thus, it is important to find a marker that would indicate the persistence of remnant tumors. Circulating tumor DNA had been a useful indicator for colon cancer recurrence, so a study, funded by Roche, was conducted to evaluate the usage of atezolizumab to manage bladder cancer in patients with circulating tumor DNA.
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Treating Urothelial Carcinoma with a Combination of Disitamab Vedotin plus Toripalimab
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on January 21st, 2026
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As a means to escape the immune system, many tumor cells express PD-1 on the surface to downregulate the immune cells that have specifically targeted them for killing. Interfere with this immune evasion method by targeting and inhibiting PD-1 had proven to be successful. The pharmaceutical RemeGen had funded a study to evaluate the added benefit of adding toripalimab - an anti-PD-1 immunotherapy - to the current therapy for urothelial carcinoma, disitamab vedotin.
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Effectiveness of High-Dose Seasonal Influenza Vaccine in Preventing Hospitalization in Older Adults
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on January 19th, 2026
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Every flu season, vulnerable populations, such as the elderly, are the most heavily affected. For these older individuals, the vaccine effectiveness at preventing hospitalization, which is already low and varied, can be worse than the average population. With funding from Sanofi, a study was conducted to test the effectiveness of a higher dose influenza vaccine; the study has recently published its findings in the New England Journal of Medicine.
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Using Valacyclovir to Treat Early Symptomatic Alzheimer’s Disease
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on January 16th, 2026
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During the latent stage after initial site infection with herpes simplex virus HSV-1 and HSV-2, the virus can infiltrate trigeminal ganglion and migrate to the brain via retrograde axonal transport. In animal study, HSV can infect neuronal and glial cells causing accumulation of amyloid β-protein, and tau protein phosphorylation, a hallmark of Alzheimer’s disease. Moreover, a postmortem study found that 90% of patients with Alzheimer’s disease had detectable HSV-1 DNA in the amyloid plaques. With funding from the United States National Institutes on Aging, a study was commissioned to examine the effectiveness of valacyclovir in treating symptomatic Alzheimer’s disease.
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Inspecting the Aspirin plus Ticagrelor Combination in Preventing Cardiovascular Exacerbation in Patients Undergoing Coronary-Artery Bypass Grafting
Topic: CARDIOLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on January 14th, 2026
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In many countries, long-term aspirin therapy is routinely recommended for patients who have undergone coronary-artery bypass grafting. More recent guidelines have suggested adding a P2Y12 inhibitor to aspirin, although the evidence supporting this approach remains limited. To address this question, a study funded by the Swedish Research Council evaluated the cardiovascular benefits and risks of combining aspirin with ticagrelor in patients following CABG.
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Managing Community-Acquired Pneumonia with Glucocorticoids in Resource-Limited Settings
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on January 12th, 2026
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Previous studies had found that glucocorticoids can help reduce the inflammation in patients with community-acquired pneumonia. However, most of these studies were conducted in well-resourced settings and excluded chronic disease commonly found in limited resource settings such as HIV and tuberculosis. With funding from the Wellcome Trust, a study was conducted to assess the usage of glucocorticoids in treating community-acquired pneumonia in a limited resource setting.
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Fish Oil Supplementation to Reduce Cardiovascular Event Risk in Patients Undergoing Hemodialysis for End-Stage Kidney Disease
Topic: CARDIOLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on January 9th, 2026
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Previous study had found that individuals with a higher blood concentration of n-3 polyunsaturated fatty acids had a lower risk of cardiovascular diseases. Many of the patients undergoing hemodialysis for end-stage kidney disease also affected with cardiovascular diseases. Additionally, these patients have a lower n-3 polyunsaturated fatty acids level than normal. With funding from the Heart and Stroke Foundation of Canada, a study was conducted to evaluate the cardiovascular effect of fish oil supplementation in patients undergoing dialysis.
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Treating Systemic Lupus Erythematosus with Cenerimod
Topic: ALLERGY & IMMUNOLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on January 7th, 2026
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Previous study had found that the sphingosine-1-phosphate (S1P) receptor is essential for the migration and function of immune cells. There had been successful attempts in regulating this target to manage autoimmune disease such as multiple sclerosis and ulcerative colitis. With funding from Amgen, a study was conducted to explore the usage of cenerimod to treat systemic lupus erythematosus.
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Long Term Effectiveness of Anifrolumab in Managing Systemic Lupus Erythematosus
Topic: ALLERGY & IMMUNOLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on January 5th, 2026
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Systemic lupus erythematosus is an autoimmune disease in which B-cells generate antibodies targeting protein endogenous to the host. Previous studies had found anifrolumab can reduce disease severity and inflammation by blocking the type I interferon signaling pathway. A long-term study on the effectiveness of anifrolumab, sponsored by AstraZeneca, had recently published its findings in the Lancet.
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Addition of Golimumab to Methotrexate/Corticosteroids to Manage Psoriatic Arthritis
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on December 22nd, 2025
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Patients with a history of skin psoriasis had a higher risk of developing psoriatic arthritis in the future. The current standard treatment regimen is a combination of corticosteroid, methotrexate, and biologic drug inhibiting the inflammatory pathway. Due to the higher cost of the biologic agents, it is frequently unavailable in developing countries. With funding from Janssen, a study was conducted to investigate the clinical effect of golimumab in treating psoriatic arthritis.
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Explore the Usage of Simvastatin with Escitalopram to Manage Depression
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on December 19th, 2025
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As Vietnam’s diet and lifestyle patterns have shifted, obesity rates have risen sharply. At the same time, improved diagnosis and changing social conditions have contributed to a growing prevalence of depression. These two conditions often occur together, compounding chronic health burdens and increasing mortality risk. With support from the German Ministry of Education and Research, researchers conducted a study to investigate whether simvastatin could help manage both depression and obesity.
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Using Esketamine to Manage Treatment-Resistant Depression
Topic: PSYCHIATRY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on December 17th, 2025
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Although many treatments are approved for major depressive disorder, about 35 percent of patients fail to respond to at least two antidepressants. These individuals are classified as having treatment-resistant depression, a condition associated with greater illness burden and a markedly increased risk of suicide. To explore alternative therapies, Janssen funded a study evaluating esketamine for this difficult-to-treat population.
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Managing Insomnia with Seltorexant, an Orexin-2 Receptor Antagonist
Topic: PSYCHIATRY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on December 15th, 2025
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Insomnia is increasingly common, yet treatment options remain limited. Currently, only two major classes of medications are approved: benzodiazepines and non-benzodiazepine hypnotics such as zolpidem. These drugs are effective for some patients but often come with drawbacks, including daytime drowsiness, dependence, tolerance, and a higher risk of cognitive impairment in older adults. To explore better alternatives, Johnson & Johnson funded a study evaluating the use of seltorexant for insomnia.
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Novel mRNA Vaccine to Prevent Seasonal Influenza
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on December 12th, 2025
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There are currently two types of vaccines used to prevent influenza: the injectable inactivated influenza vaccine and the live attenuated influenza vaccine. Drawing on experience gained from developing the COVID-19 mRNA vaccines, Pfizer has applied mRNA vaccine technology to create a new influenza vaccine. A study evaluating its safety and effectiveness was recently published in the New England Journal of Medicine.
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Effectiveness of Beta Blockers in Preventing Cardiovascular Problems in Patients with a History of Myocardial Infarction
Topic: CARDIOLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on December 10th, 2025
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Beta blockers have long been prescribed to prevent recurrent myocardial infarction, largely because of their antiarrhythmic properties. However, much of the evidence supporting this practice comes from studies conducted more than 40 years ago-before the widespread use of contemporary coronary reperfusion therapy. Their benefit in patients with preserved or mildly reduced left ventricular ejection fraction also remains uncertain. To address this gap, a government-funded study in Norway evaluated the effectiveness of beta blockers in a modern clinical context.
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Treating Advanced Triple Negative Breast Cancer with Sacituzumab Govitecan
Topic: ONCOLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on December 8th, 2025
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Patients with breast tumors that lack expression of the three major hormone receptors face poorer outcomes than others. These triple-negative breast cancers have a 5-year case-fatality rate of roughly 85%. Although blocking the PD-1 immune-evasion pathway can be effective, such immunotherapies offer little benefit when tumors do not express or downregulate PD-1. To address this challenge, a Gilead-funded study evaluated sacituzumab govitecan as a treatment option for triple-negative breast cancer.
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Pain Management with Dexmedetomidine in Patients with Traumatic Rib Fractures
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on December 5th, 2025
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Pain control in patients with traumatic rib fractures is difficult to achieve. Common options such as acetaminophen, NSAIDs, and muscle relaxants often provide insufficient relief, while stronger agents like opioids carry risks of addiction and respiratory depression. To explore alternative strategies, researchers at the University of California conducted a study evaluating dexmedetomidine for pain management in this population.
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Weight Management with GLP-1 Receptor Agonist, Orforglipron
Topic: DIABETES & ENDOCRINOLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on December 3rd, 2025
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Overweight and obesity substantially raise the risk of numerous chronic diseases. GLP-1 receptor agonists have been shown to improve glycemic control, support weight loss, and lower cardiovascular risk. Orforglipron, a GLP-1 agonist already used for type 2 diabetes, was evaluated in a study funded by Eli Lilly to explore its effectiveness for weight management.
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Oral Interleukin-23 Inhibitor, Icotrokinra, to Manage Moderate to Severe Plaque Psoriasis
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on December 1st, 2025
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Plaque psoriasis is an inflammatory skin condition driven by an overactive immune response. Treatments that target pro-inflammatory pathways-such as interleukin-12 (IL-12), IL-17, IL-23, and TNFα-have been effective, but most require injectable administration. The need for regular clinic visits can reduce adherence, while existing oral treatments tend to be less effective. To address this gap, a Johnson & Johnson–funded study evaluated the oral agent icotrokinra for the treatment of plaque psoriasis.
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Prevent Stroke Recurrence in Diabetic Patients with Liraglutide
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on November 28th, 2025
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Individuals with diabetes face an elevated risk of ischemic stroke, and they are more likely to experience recurrent events. Prior research suggests that glycemic control alone-whether through insulin or sulfonylureas-does not fully account for this risk, indicating that additional mechanisms such as inflammation or insulin resistance may contribute to recurrence. With support from the Chinese government, researchers conducted a study to evaluate whether liraglutide could reduce the risk of stroke and transient ischemic attack in patients with diabetes.
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Combination of Amivantamab and Lazertinib to Treat Non–Small Cell Lung Cancer
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on November 26th, 2025
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Chemotherapies that target the epidermal growth factor receptor signaling pathway (EGFR-TKIs) have been central to treating non–small cell lung cancer (NSCLC). However, even the most advanced third-generation agents offer only moderate benefit, with median survival around three years and a 5-year survival rate below 20%. Resistance to current therapies continues to emerge, highlighting the need for new treatment strategies. With support from Janssen, researchers conducted a study evaluating the combined use of amivantamab and lazertinib in NSCLC.
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Novel Live Attenuated Vaccine to Prevent Salmonella Paratyphi Enteric Fever
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on November 24th, 2025
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Enteric fever caused by Salmonella enterica can be largely prevented through improved water and sanitation systems. Vaccination against the typhi serotype—the agent responsible for typhoid fever—has played a major role in reducing disease burden. However, no licensed vaccine has been available for the paratyphi serotype. With support from the United Kingdom’s Medical Research Council, researchers conducted a study to evaluate CVD 1902, a new vaccine designed to protect against Salmonella Paratyphi A.
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Using Sotatercept to Manage Pulmonary Arterial Hypertension
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on November 21st, 2025
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Pulmonary arterial hypertension (PAH) is characterized by the narrowing of pulmonary blood vessels, which limits blood flow to the lungs and impairs gas exchange. Current treatment options offer only partial benefit and do not fully halt disease progression, morbidity, or mortality. Supported by Merck, a recent study investigated the potential of sotatercept as a novel therapy for managing PAH.
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Efficacy and Safety of Aspirin with Anticoagulant in Patients with High Risk of Thrombotic Events
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on November 19th, 2025
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Long-term anticoagulation therapy is commonly prescribed to prevent recurrent thrombotic events in patients with chronic coronary disease. While previous studies have shown that combining anticoagulant and antiplatelet therapy increases bleeding risk, many of those trials were limited by a lack of blinding and the inclusion of predominantly low-risk patients. To address these limitations, a study funded by the French Ministry of Health and Bayer investigated whether adding aspirin to an anticoagulant regimen would provide additional benefits in patients at high risk of thrombotic events.
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Investigate the Effectiveness of Carbocisteine & Hypertonic Saline for Bronchiectasis Management
Topic: RESPIRATORY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on November 17th, 2025
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Patients with bronchiectasis often experience excessive mucus production that interferes with normal respiratory function. Current clinical guidelines recommend the use of mucoactive medications and airway clearance agents to facilitate sputum expectoration, but these recommendations are largely based on low-quality evidence. To address this gap, the British government funded a study to evaluate the safety and efficacy of mucolytic therapy in bronchiectasis management.
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Addition of Vitamin B to Dexketoprofen to Manage Cervical Muscle Sprain Pain
Topic: ORTHOPEDIC
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on November 14th, 2025
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Cervical muscle pain is commonly treated with non-steroidal anti-inflammatory drugs (NSAIDs) and muscle relaxants; however, these therapies often provide limited relief and are associated with considerable adverse effects. To identify alternative treatment options, the pharmaceutical company, Laboratorios Silanes, funded a study investigating the potential benefit of adding a vitamin B complex supplement to dexketoprofen therapy.
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Prednisone Therapy to Manage Pain & Improve Function in Patients with Acute Lumbar Radiculopathy
Topic: ORTHOPEDIC
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on November 12th, 2025
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Acute lumbar radiculopathy is a common condition that will affect around 10% of the population at least once throughout their lifetime. Spontaneous recovery can happen, but the affected person can experience significant pain and disability. More invasive treatment such as disketomy or epidural steroid injections can be utilized, but they are associated with significant challenges. With funding from the US National Institutes of Health, a study was conducted to examine the usage of oral steroids to manage lumbar radiculopathy.
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Compare Cefiderocol to Standard Antimicrobial Therapy in Treating Nosocomial Bloodstream Infection with Gram-Negative Bacteria
Topic: INFECTIOUS DISEASE
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on November 10th, 2025
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Hospital-acquired infections, particularly bloodstream infections, are responsible for millions of deaths each year. Mortality risk is markedly higher among patients infected with gram-negative bacteria resistant to multiple antimicrobial agents. Supported jointly by the governments of Singapore and Australia, a clinical study was conducted to evaluate the efficacy of cefiderocol, a novel antibiotic, for the treatment of nosocomial bacteremia.
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Using 0.03% Roflumilast Foam to Treat Plaque Psoriasis Affecting the Scalp
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on November 7th, 2025
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Treating plaque psoriasis affecting the scalp is challenging because the presence of hair can interfere with the application of topical agents in the form of ointment or cream. However, newer delivery methods such as foam might be more effective and suitable with hair care practice. With funding from Arcutis Biotherapeutics, a study was conducted to assess the usage of roflumilast foam to manage plaque psoriasis.
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Treating Moderate to Severe Atopic Dermatitis with Ivarmacitinib
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on November 5th, 2025
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The inflammation and itching characteristic of atopic dermatitis are driven primarily by the cytokines IL-4, IL-13, and IL-31. Current therapies target these cytokines or their downstream signaling proteins, such as the Janus kinase (JAK) family; however, their efficacy remains limited and adverse effects are common. To address these challenges, Jiangsu Hengrui Pharmaceuticals funded a study to evaluate the efficacy and safety of ivarmacitinib, a selective JAK inhibitor, for the treatment of atopic dermatitis.
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Effect of Nicotinamide Cream in Preventing Skin Cancer
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on November 3rd, 2025
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Previous clinical trials have suggested that nicotinamide supplementation may help prevent skin cancer; however, these studies were limited by small sample sizes. To further investigate its effectiveness, a large-scale study funded by the US government evaluated the use of topical nicotinamide in skin cancer prevention.
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Blocking Cytokine Promoting B-Lymphocyte Activity with Telitacicept to Manage Systemic Lupus Erythematosus
Topic: ALLERGY & IMMUNOLOGY
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on October 31st, 2025
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Systemic lupus erythematosus is an autoimmune disease driven by B-lymphocyte. There are many available therapies for the condition; however, their effectiveness and safety profile are not optimal. Cytokines such as B-lymphocyte stimulator (BLyS) and APRIL are important for the pathogenesis of lupus. With funding from RemeGen, a study was conducted to assess the usage of Telitacicept, an cytokine-targeting agent, in managing lupus.
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Using Permethrin-Treated Cloths for Baby Wrap to Prevent Malaria
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on October 29th, 2025
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Despite recent progress in malaria management, the disease still imposes a significant burden especially in children living in underdeveloped nations. Factors such as insecticide resistance and change in mosquito biting habit had kept transmission persistent. With funding from Doris Duke Foundation, a study was conducted to investigate the usage of permethrin-treated cloths to prevent malaria in infants.
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Managing Treatment-Resistant Hypertension with Baxdrostat
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on October 27th, 2025
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Elevated aldosterone level is associated with uncontrolled or treatmen-resistant hypertension. Baxdrostat is an aldosterone synthase inhibitor that has extensive biological functions due to the long half-life of 30 hours. The medication can reduce aldosterone level, which reduces sodium and water retention that causes the high blood pressure. With funding from AstraZeneca, a study was conducted to investigate the usage of baxdrostat in hard-to-treat hypertension cases.
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Respiratory Syncytial Virus Prevention with Clesrovimab
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on October 24th, 2025
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Respiratory syncytial virus infection is the leading cause of infant hospitalization, with the disease severity highest for infants below 6 months old. Many studies had found monoclonal antibodies such as nirsevimab and palivizumab to be an effective preventive measure for RSV infection in infants. With funding from Merck, a study was conducted to investigate the usage of clesrovimab to prevent RSV infection in young children.
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Managing Hypertriglyceridemia with Olezarsen, an Oligonucleotide Targeting Apolipoprotein C-III mRNA
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on October 22nd, 2025
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Apolipoprotein C-III (APOC3) inhibits triglyceride clearance by interfering with lipoprotein lipase activity. Olezarsen, an antisense oligonucleotide, targets and neutralizes APOC3 mRNA to enhance triglyceride metabolism. Supported by Ionis Pharmaceuticals, a study was conducted to evaluate the efficacy of olezarsen in managing hypertriglyceridemia.
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Compare Oral to Intravenous Rehydration for Severedly Malnourished Children in Resource Limited Settings
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on October 20th, 2025
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For children hospitalized with severe malnutrition, rehydration therapy is often indicated. Oral rehydration is traditionally preferred over intravenous administration due to concerns that malnourished children may have compromised cardiac function, which could be further stressed by fluid overload. However, this recommendation is based on limited evidence from decades-old studies. To address this knowledge gap, the Joint Global Health Trials organization funded a study to evaluate the safety and effectiveness of intravenous rehydration in children with severe malnutrition.
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Preventing Venous Thromboembolism with Apixaban in High-Risk Individuals
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on October 17th, 2025
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For patients with low risk venous thromboembolism provoked by cancer or thrombophilia, anticoagulants could be used for 3 months. However, it is currently unclear of the appropriate anticoagulant duration for low risk venous thromboembolism provoked by obesity, surgery, or immobility. With funding from Bristol-Myers Squibb & Pfizer, a study was implemented to determine the optimal schedule of apixaban to prevent transient provoked venous thromboembolism.
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Using Digitoxin to Manage Heart Failure Cases with Reduced Ejection Fraction
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on October 15th, 2025
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Cardiac glycosides such as digoxin are frequently prescribed to manage heart failure. However, previous studies have found digoxin to have limited effectiveness in managing heart failure with reduced ejection fraction. Due to recent advancement in other cardiovascular therapy, the German government has sponsored a study to examine the usage of digitoxin to manage heart failure with reduced ejection fraction.
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Tirofiban as an Adjunct to Thrombolysis in Ischemic Stroke
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on October 13th, 2025
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For ischemic stroke, intravenous thrombolysis is recommended within 4.5 hours of onset. However, even with timely treatment, more than half of patients fail to regain full function. To increase treatment efficacy, the Chinese government funded a study to evaluate whether tirofiban could improve recovery outcomes when added to standard thrombolysis.
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Weight Management with Reduced-Dose Oral Semaglutide
Topic: DIABETES & ENDOCRINOLOGY
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on October 10th, 2025
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Semaglutide, initially approved as a subcutaneous injection for type 2 diabetes, is now also available in an oral formulation. Beyond glycemic control, semaglutide has been shown to promote significant weight reduction. A recent Novo Nordisk–funded study evaluated the effect of a lower oral dose of semaglutide in managing obesity.
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Managing Type 2 Diabetes with Oral GLP-1 Agonist, Orfoglipron
Topic: DIABETES & ENDOCRINOLOGY
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on October 8th, 2025
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Activation of GLP-1 receptors is a well-established strategy for managing type 2 diabetes, with agents such as semaglutide and tirzepatide also showing benefits for weight loss and cardiovascular health. However, their use is complicated by the need for injection. Orfoglipron, a small-molecule oral GLP-1 receptor agonist, offers a potentially simpler alternative. Supported by Eli Lilly, a study was conducted to evaluate its efficacy in type 2 diabetes.
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Aspirin Use in Colorectal Cancer With PI3K Mutations
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on October 6th, 2025
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Aspirin, a widely used analgesic and anti-inflammatory agent, reduces inflammation by inhibiting cyclooxygenase-2 (COX-2). Colorectal cancer tumors often overexpress COX-2, which activates the phosphatidylinositol 3-kinase (PI3K) pathway and promotes tumorigenesis. Supported by the Swedish Research Council, researchers conducted a study to evaluate whether aspirin could improve outcomes in patients with colorectal cancer harboring PI3K pathway mutations.
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Lumateperone as Adjunct Therapy for Major Depressive Disorder
Topic: PSYCHIATRY
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on October 3rd, 2025
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Major depressive disorder (MDD) is a highly prevalent condition that profoundly affects quality of life, yet standard antidepressant treatment achieves remission in only about half of patients. Efforts to enhance efficacy with adjunctive antipsychotics have been limited by poor tolerability and high rates of treatment discontinuation. To address this, Johnson & Johnson funded a study evaluating lumateperone, a novel antipsychotic, as an adjunct to traditional antidepressants in the management of major depressive disorder.
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Lubiprostone and Renal Function in Chronic Kidney Disease
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on October 1st, 2025
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Lubiprostone, a chloride channel activator commonly used to treat constipation, has been linked in previous large-scale observational studies to a lower risk of renal complications in patients with chronic kidney disease (CKD). To investigate this potential renoprotective effect further, the Japan Agency for Medical Research and Development funded a study examining lubiprostone in CKD patients.
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Investigate the Cardiovascular Effects of Interleukin-17 Inhibitors
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on September 29th, 2025
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Previous research suggested a possible link between interleukin-17 (IL-17) inhibitor use in psoriasis and an increased risk of major cardiovascular events, potentially due to the role of IL-17 in collagen production. By lowering IL-17 levels, therapies targeting T-helper 17 cells may destabilize atherosclerotic plaques, increasing the risk of vascular blockage. To investigate this further, a study was funded by the French Society of Dermatology to examine the cardiovascular safety of IL-17 inhibitors.
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Vedolizumab for Preventing Post-Surgical Recurrence in Crohn’s Disease
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on September 26th, 2025
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Despite successful surgical resection, many patients with Crohn’s disease relapse within the first year, and no medical therapy is currently approved to prevent recurrence following surgery. Vedolizumab, already approved for Crohn’s disease and ulcerative colitis, has been investigated for its potential use in this setting through a study funded by Takeda.
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Evaluating Ziresovir for the Treatment of Respiratory Syncytial Virus Infection in Infants
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on September 24th, 2025
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Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infection and hospitalization in infants and young children. Current recommendations advise vaccinating children born during, or about to enter, their first RSV season. However, vaccination is not always feasible, highlighting the need for effective antiviral therapies. To address this gap, a study funded by Shanghai Ark Biopharmaceutical investigated the use of ziresovir in treating RSV infection in young children.
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Evaluating Single-Dose Versus Multi-Dose Benzathine Penicillin G for Syphilis Treatment
Topic: INFECTIOUS DISEASE
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on September 22nd, 2025
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Although syphilis is a manageable infection, its incidence has been rising in recent years. Current guidelines in Western countries recommend treatment with long-acting penicillin, specifically benzathine penicillin G, yet there is no clear consensus on the optimal dosing regimen. In light of recent shortages of this medication, the U.S. National Institute of Allergy and Infectious Diseases sponsored a study to compare the effectiveness of one versus three doses of benzathine penicillin G for treating syphilis.
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Preventing Disease Recurrence with Cemiplimab in Patients Undergone Surgical Resection for Cutaneous Squamous Cell Carcinoma
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on September 19th, 2025
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Cutaneous squamous-cell carcinoma is one of the most common forms of skin cancer, and it can easily be managed with surgical resection. In cases of recurrent disease, radiotherapy can be used, but treatment failure can still occur in certain patients. A study was funded by Sanofi & Regeneron Pharmaceuticals with the aims to explore the usage of cemiplimab in treating cutaneous squamous cell carcinoma in patients with a high likelihood of relapse.
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Using Elinzanetant to Manage Hot Flashes in Breast Cancer Patients Treated with Endocrine Therapy
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on September 17th, 2025
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For patients with hormone receptor–positive breast cancer, endocrine therapy is typically prescribed for five to ten years. While effective, this prolonged treatment often causes vasomotor side effects, most notably hot flashes, which tend to be more severe in younger patients who have not yet experienced menopause. With funding from Bayer, a study was conducted to evaluate the effectiveness of elinzanetant in reducing hot flashes during breast cancer treatment.
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Nirsevimab Provides Extended Protection Against RSV-Associated Hospitalization in Infants
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on September 15th, 2025
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Nirsevimab is a monoclonal antibody that targets the F protein used by respiratory syncytial virus (RSV) to enter host cells. Earlier studies demonstrated its effectiveness in preventing hospitalization among children, but with a half-life of 71 days, it remained unclear whether protection would extend across the typical four-month RSV season. To address this question, Sanofi and AstraZeneca sponsored a study evaluating the long-term protective effect of nirsevimab.
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Infection Risk in Schizophrenia Patients Treated with Clozapine
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on September 12th, 2025
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Clozapine is an antipsychotic commonly used to manage schizophrenia. Unintentionally, the medication has an immunomodulatory effect. In vitro study has found that clozapine can reduce neutrophil count, promote interleukin-6 production, and suppress B-cell activity. Usage of the antipsychotic is also associated with a higher incidence of respiratory infection. A study, recently published in the Lancet, was performed to assess the risk of infection associated with clozapine usage.
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Examines Darbepoetin for Neurodevelopment in Preterm Infants
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on September 10th, 2025
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Preterm infants face a markedly higher risk of neurodevelopmental complications. Previous research has suggested that stimulating red blood cell production with erythropoietin may have neuroprotective effects. To further investigate this potential, a study recently published in the Journal of American Medical Association evaluated whether darbepoetin could improve neurodevelopmental outcomes in preterm infants.
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Combining Semaglutide and Cagrilintide for Weight Management
Topic: DIABETES & ENDOCRINOLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on September 8th, 2025
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In addition to lifestyle and dietary change, obesity can also be managed with pharmacotherapy options. Semaglutide, first used for diabetes, had been implemented for weight management. With the medication yielding promising results, there had been a continuous push to explore other approaches. A study, funded by Novo Nordisk, was conducted to explore the usage of semaglutide in combination with cagrilintide to manage obesity.
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Risk of Heart Failure in Pregabalin and Gabapentin Usage
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on September 5th, 2025
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Pregabalin and gabapentin are frequently used to manage chronic pain. These gabapentinoids are preferred over opioids due to the risk of addiction development. However, these medications are associated with risk of cardiovascular side effects, but there is still a lack of thorough understanding. With funding from the United States National Institute of Arthritis and Musculoskeletal and Skin Diseases, a study was conducted to assess the cardiovascular risk of pregabalin and gabapentin usage.
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Treating Breast Cancer with Mutated Estrogen Receptor with Camizestrant
Topic: ONCOLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on September 3rd, 2025
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Aromatase inhibitor and CDK 4/6 inhibitor are frequently used as first-line treatment for breast cancer tumor expressing hormone receptors. However, mutation to the estrogen receptor might interfere with the binding of the antagonist aromatase inhibitor. To circumvent this resistance mechanism, AstraZeneca funded a study that tested camizestrant, an selective estrogen-receptor degrader, as a therapy for breast cancer.
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Combination Therapy of Finerenone and Empagliflozin to Manage Kidney Health in Patients with Type 2 Diabetes and Chronic Kidney Disease
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on September 1st, 2025
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Sodium–glucose cotransporter-2 (SGLT2) inhibitors and nonsteroidal mineralocorticoid receptor antagonists are frequently used in patients with chronic kidney disease and type 2 diabetes. The effectiveness of these monotherapy is clearly understood, but little is known about the combination effect. With funding from Bayer, a study was conducted to assess the dual usage of these medications to prevent kidney disease progression.
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Investigating the Link between Marijuana Usage and Cardiovascular Disease
Topic: CARDIOLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on August 29th, 2025
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With the usage of marijuana becoming more prevalent, it is important for healthcare professionals to understand the risk and benefits of the substance. There had been studies that linked easing anxiety, chronic pain, and others. However, there had also been others that found marijuana to increase the risk of other health conditions. To address this knowledge gap, the United States National Heart, Lung, and Blood Institute had sponsored a study to investigate the association between marijuana and cardiovascular health.
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Comparing the Effectiveness between Donor and Formula Milk for Preterm Infants
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on August 27th, 2025
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Maternal milk is the most valuable nutrient source for young children; however, preterm infants had difficulty with breastfeeding. Additionally, mothers who gave birth preterm may have problems with milk production. Thus, alternative methods must be utilized until maternal milk can be delivered. With funding from the Australian National Health and Medical Research Council, a study was conducted to compare the usage of formula milk and donor milk in preterm infants.
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Treating Recurrent or Metastatic Breast Cancer with Vepdegestrant, an Estrogen Receptor Degrader
Topic: ONCOLOGY
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on August 25th, 2025
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A majority of breast cancer tumors exhibit estrogen receptors on their surface while not having the receptor for human epidermal growth factor (HER2). To target this form of cancer, endocrine therapy is used in conjunction with CDK4/6 inhibitors, but treatment resistance poses a challenge for the management of disease progression. With funding from Pfizer, a study was conducted to examine the usage of vepdegestran in advanced breast cancer.
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Treating Non-Small-Cell Lung Cancer with Limertinib, a 3rd Generation EGFR Inhibitor
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on August 22nd, 2025
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Mutation to the epidermal growth factor receptor (EGFR) significantly increases the risk of non-small-cell lung cancer (NSCLC). As a result, inhibiting the EGFR signaling pathway becomes an ideal therapeutic target. EGFR tyrosine kinase inhibitors have been shown to be effective at managing NSCLC, but resistance has been shown to be an obstacle. With funding from Jiangsu Aosaikang Pharmaceutical, a study was conducted to investigate the usage of limertinib to treat non-small-cell lung cancer.
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Treating Long-COVID with Nirmatrelvir and Ritonavir
Topic: COVID-19
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on August 20th, 2025
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The pathogenic cause behind long COVID is poorly understood; it has been hypothesized that factors such as immune dysregulation, microbiome dysbiosis, and other factors can play a role. Viral persistence had also been suggested to be associated with long COVID. With funding from Pfizer, a study was conducted to examine whether antiviral therapy can alleviate long COVID.
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Mass Administration of Ivermectin to Control the Spread of Malaria
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on August 18th, 2025
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Malaria is a widespread mosquito-borne disease that can be effectively controlled with insecticide and the usage of bed nets. However, insecticide resistance and behavior adaptation of the vector can pose significant challenges to the current public health intervention. With funding from the international organization UNITAID, a study was conducted to assess the usage of ivermectin to prevent malaria transmission.
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Tartalamab as a Second-Line Therapy for Small-Cell Lung Cancer
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on August 15th, 2025
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Small-cell lung cancer is one of the most severe with only 5% of the patients surviving past 5 years. Platinum-based chemotherapy and PD-L1 inhibitors are the first-line therapy for the condition; however, these therapies do not significantly increase survivability. Existing second-line therapies are equally ineffective with intolerable hematological side effects. With funding from Amgen, a study was conducted to assess the usage of tarlatamab to treat small-cell lung cancer.
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Treating HER2-Positive Gastric Cancer with Trastuzumab Deruxtecan
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on August 13th, 2025
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Gastric cancer is one of the most prevalent cancers in Vietnam, and it is associated with significant quality of life deterioration. Previous studies had found that between 5% and 17% of gastric cancer tumors express human epidermal growth factor receptor 2 (HER2). The pharmaceutical companies Daiichi Sankyo and AstraZeneca had co-funded a study to take advantage of this new therapeutic target - using trastuzumab deruxtecan to treat gastric cancer.
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Comparing the Effectiveness of Weekly Insulin Injection to Daily Injection in Managing Type 2 Diabetes
Topic: DIABETES & ENDOCRINOLOGY
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on August 11th, 2025
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For patients with type 2 diabetes, insulin injection is recommended if standard glucose-reducing agents cannot achieve effective glycemic control. Daily insulin injections pose significant challenges to patients and can reduce treatment adherence. Eli Lilly had sponsored a study to assess the feasibility of a once-weekly insulin injection to manage blood glucose level.
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Post-Discharge Ondansetron for Children with Gastroenteritis
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on August 8th, 2025
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Ondansetron is a 5-hydroxytryptamine type 3 (5-HT3) receptor antagonist that is frequently used to suppress nausea in children hospitalized due to acute gastroenteritis. The value of post-discharged ondansetron usage is unclear. As a result, the Canadian Institutes of Health Research funded a study to evaluate the effect of after-discharged benefit of ondansetron.
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Methotrexate vs. Prednisone as the First Line Treatment for Pulmonary Sarcoidosis
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on August 6th, 2025
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Prednisone is the first-line therapy to treat the inflammation associated with pulmonary sarcoidosis. However, this treatment is recommended based on dated and low quality studies. Additionally, prolonged prednisone usage is associated with significant side effects. Recently, a study funded by the Dutch Lung Foundation was conducted to evaluate the replacement of prednisone with methotrexate in treating pulmonary sarcoidosis.
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Supplement Durvalumab to the Standard FLOT Chemotherapy for Resectable Gastric and Gastroesophageal Adenocarcinoma
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on August 4th, 2025
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Gastric and gastroesophageal adenocarcinoma is one of the most common cancers in Vietnam. Surgical resection with chemotherapy is the ideal way to treat the tumor; however, recurrence is still high. Interfering with the tumor’s immunosuppressive effect had been found to be effective at disease management. A study funded by AstraZeneca was conducted to analyze the addition of durvalumab to the standard chemotherapy to manage gastric and gastroesophageal cancer.
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Adding Inavolisib to the Current Palbociclib-Fulvestrant Therapy to Treat Breast Cancer
Topic: ONCOLOGY
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on August 1st, 2025
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Hormone receptor-positive breast cancer has a complicated pathogenesis with different pathways influencing tumorigenesis. The 3 significant markers associated with disease include estrogen receptor, cyclin-dependent kinase 4 & 6 (CDK4/6), and phosphatidylinositol 3-kinase (PI3K). Of them, mutation to the latter, specifically the PIK3CA mutation is found in 40% of patients and is associated with worse prognosis. With funding from Roche, a study was conducted to investigate the addition of inavolisib to the current therapy to treat breast cancer.
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Tenecteplase Thrombolysis before Thrombectomy in Patients with Ischemic Stroke
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on July 30th, 2025
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Intravenous thrombolysis before endovascular thrombectomy is associated with benefit in the form of enhancing perfusion but with the increased risk of hemorrhage. Several previous studies had found inconsistent results, but most of the studies were conducted with alteplase. With funding from the Chinese government, a study was conducted to assess the usage of tenecteplase before thrombectomy for stroke patients.
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Combining Albuterol and Budesonide to Prevent Asthma Exacerbation
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Reviewed & Translated by Dat Tien Nguyen, B.A, ScM.
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Posted on July 28th, 2025
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Short-acting β2-agonist, such as albuterol. is frequently used to prevent and treat asthma exacerbation. However, its lack of immunomodulation property limits its effectiveness. Therefore, combining albuterol and an inhaled glucocorticoids like budesonide increases the efficacy beyond monotherapy. A study funded by AstraZeneca was conducted to analyze the combination of albuterol and budesonide to prevent exacerbation in mild asthma.
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Inhibiting HDL to LDL Conversion with Obicetrapib to Manage Hypercholesterolemia
Topic: CARDIOLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on July 23rd, 2025
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High serum low-density lipoprotein (LDL) cholesterol level had been associated with a higher risk of cardiovascular events. Treatment such as statin might not yield the needed degree of clinical improvement and dose escalation might be limited by side effects. With funding from New Amsterdam Pharma, a study was conducted to evaluate the usage of obicetrapib to manage blood cholesterol level.
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Compare the Weight Reduction Effect between Semaglutide and Tirzepatide
Topic: DIABETES & ENDOCRINOLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on July 21st, 2025
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Semaglutide and tirzepatide are novel treatments for diabetes, but due to their clinical benefit, have become popular options in many Western countries. Both of these medications had been associated with significant beneficial metabolic improvement such as weight reduction. A study funded by Eli Lilly recently published in the New England Journal of Medicine had compared the weight management effect between semaglutide and tirzepatide.
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Combining JAK-Inhibitor Baricitinib and Narrow Band UV-B Phototherapy to Treat Vitiligo
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on July 18th, 2025
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Vitiligo is a skin depigmentation disorder caused by melanocyte destruction by immune cells. The condition is traditionally treated with UV-B phototherapy. However, since this process is mediated by both interferon alpha produced by dendritic cells and interleukin-13 from type 2 T-cell response. Medications that interfere with this pathway, like ruxolitinib and baricitinib, can be used to manage the condition. With funding from Eli Lilly, a study was conducted to evaluate the combined effect of baricitinib and UV-B phototherapy in treating vitiligo.
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Assessing the Risk of Neuropsychiatric Adverse Events with Montelukast Usage in Children & Adolescents
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on July 16th, 2025
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Montelukast is widely used to manage asthma and allergic rhinitis in children and adolescents. However, recent surveillance data had found an association between montelukast usage and the frequency of neuropsychiatric adverse events. Yet, the mechanism behind this effect is not well understood, but it is hypothesized that the agent can interfere with the hypothalamic-pituitary-adrenal axis. With funding from the Swedish Asthma and Allergy Association, a study was conducted to assess the potential neuropsychiatric side effect of montelukast.
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Effectiveness of Live-Attenuated Chikungunya Vaccine, VAL1553
Topic: INFECTIOUS DISEASE
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on July 14th, 2025
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Chikungunya is a viral infection by the CHKV virus which is associated with arthralgia and myalgia. The virus is transmitted by the Aedes aegypti and Aedes albopictus mosquitoes, which is commonly found across Asia. With funding from the pharmaceutical company Valneva Austria and the European Union, a study was conducted to assess the effectiveness of a vaccine to prevent chikungunya infection.
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Manage Metabolic Dysfunction-Associated Steatohepatitis with Efruxifermin
Topic: GASTROINTESTINAL
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on July 11th, 2025
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As the frequency of obesity increases in Vietnam, physicians need to prepare for a paired increase in metabolic dysfunction-associated steatohepatitis (MASH) cases. Beside dietary interventions and lifestyle modification, there are some viable therapies in the form of GLP-1 agonists and resmetiron; however, there is an increased need for other treatments to treat patients who cannot be treated with the remaining options. With funding from Akero Therapeutics, a study was conducted to evaluate the usage of efruxifermin to manage MASH.
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Low-Sodium Salt Substitutes and Stroke Recurrence
Topic: CARDIOLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on July 9th, 2025
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With the increase in the frequency of cardiovascular disorders in developing and recently developed nations, the rate of stroke has also risen. High sodium diet is a risk factor for these conditions, due to its contribution to fluid accumulation that increases blood pressure. A study was conducted with funding from the Chinese government to explore the potential of using a salt substitution in preventing stroke recurrence.
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Anti-CD19 Inebilizumab in Managing Myasthenia Gravis
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on July 7th, 2025
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Myasthenia gravis is an autoimmune disease in which B cells produce antibodies targeting the acetylcholine receptor at the neuromuscular junction. The disease can be managed by anti-inflammatory glucocorticoid and cholinesterase inhibitors to increase the signal duration at the neuromuscular junction. Targeting the B-cells producing autoantibody is another option with rituximab targeting the CD20 marker on B-cells. Inebilizumab is another viable option that targets another marker on B-cells. Amgen had sponsored a study to evaluate its effectiveness in managing myasthenia gravis.
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Mazdutide Demonstrates Promising Weight Loss Results
Topic: DIABETES & ENDOCRINOLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on July 4th, 2025
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Many developing and recently developed countries, including Vietnam, are witnessing a rising prevalence of obesity. Glucagon receptor agonists—originally designed to manage type 2 diabetes—have shown potential in supporting weight loss. One such agent, mazdutide, was evaluated for its weight management effects in a study sponsored by Innovent Biologics.
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Trimethoprim–Sulfamethoxazole Fails to Prevent Adverse Birth Outcomes in Zimbabwean Trial
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on July 2nd, 2025
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Adverse birth outcomes, such as preterm birth and low birth weight, continue to pose a major public health challenge in many low-resource settings. Maternal inflammation and infections—including bacteriuria and syphilis—have been linked to higher risks of these outcomes. Based on this association, researchers conducted a study funded by the Wellcome Trust to evaluate whether prophylactic use of trimethoprim–sulfamethoxazole could reduce these risks during pregnancy.
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Semaglutide Shows Promise in Treating Metabolic Dysfunction-Associated Steatohepatitis
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on June 30th, 2025
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Currently, there is no approved treatment for metabolic dysfunction-associated steatohepatitis. With the condition heavily linked to obesity and diabetes, a study was funded by Novo Nordisk to examine the usage of semaglutide in managing liver health in patients with liver fibrosis and steatohepatitis.
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Semaglutide Found to Lower Cardiovascular Risk in Patients with Type 2 Diabetes
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on June 27th, 2025
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Those affected with type 2 diabetes experience an elevated risk of cardiovascular disease. Previous study examining the glycemic control of semaglutide, a GLP-1 receptor agonist, had found that it also reduced the risk of cardiovascular disease. To fully explore this relationship, Novo Nordisk had sponsored a study to examine the effect of semaglutide on cardiovascular health in patients with type 2 diabetes.
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Early Antiviral Therapy in Chronic Hepatitis B Shows Promise in Preventing Liver Complications
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on June 25th, 2025
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Chronic hepatitis B infection is a well-established risk factor for liver cirrhosis and hepatocellular carcinoma. While antiviral medications are effective in managing the disease, current treatment guidelines typically recommend delaying initiation until elevated liver enzymes are detected. However, recent observational data suggest that viremia alone may contribute to increased cancer risk, regardless of enzyme levels. In response, the Government of South Korea, in collaboration with Gilead, funded a study to evaluate the benefits of early antiviral intervention in patients with normal liver enzyme levels.
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Comparing the Ceftolozane–Tazobactam & Ceftazidime–Avibactam Combinations in Treating Multidrug Resistant Pseudomonas aeruginosa
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on June 23rd, 2025
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Pseudomonas aeruginosa is a prevalent bacterial pathogen, and infections caused by multidrug-resistant strains pose a significant clinical threat. While the antibiotic combinations ceftolozane–tazobactam and ceftazidime–avibactam have shown efficacy against resistant strains, limited data exist comparing their performance across different clinical scenarios. To address this gap and support the refinement of treatment guidelines, a study funded by Merck was conducted to evaluate their relative effectiveness.
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Managing Pulmonary Arterial Hypertension with Sotatercept
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on June 20th, 2025
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Pulmonary arterial hypertension, if left untreated or poorly controlled, can progress to right ventricular failure and ultimately lead to death. While current therapies can slow disease progression, they have not demonstrated a consistent ability to prevent critical outcomes such as hospitalization, lung transplantation, or mortality. To address this unmet need, a study funded by Merck investigated the use of sotatercept as a potential disease-modifying therapy for PAH.
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Sofosbuvir-Based Therapies for Children With Hepatitis C
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on June 18th, 2025
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Hepatitis C treatments that are effective in adults—such as pegylated interferon and ribavirin—have been associated with developmental complications in pediatric populations. Although the World Health Organization recommends the use antiviral, the long-term safety of these therapies in children remains uncertain. To address this gap, a study funded by Gilead Sciences was conducted to evaluate the long-term safety and efficacy of sofosbuvir in children.
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Nirsevimab Demonstrates Durable Efficacy in Preventing RSV-Related Hospitalizations in Children
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on June 16th, 2025
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Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections in infants. Nirsevimab, a monoclonal antibody that targets the RSV F protein to block viral fusion, has previously shown promise in preventing infection. A recent study funded by AstraZeneca and Sanofi has now reported on the long-term protective effects of nirsevimab.
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Impact of Long-Term Tiotropium Usage on Dementia Risk
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on June 13th, 2025
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Medications that interfere with acetylcholine signaling have been linked to cognitive decline. Long-acting antimuscarinic agents like tiotropium, commonly prescribed for chronic obstructive pulmonary disease (COPD), have known anticholinergic effects, but their impact on neurological function remains unclear. Previous studies on this topic have been limited by poor design. To address this gap, a study funded by the Brain Canada Foundation examined whether tiotropium use is associated with an increased risk of developing dementia.
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Oral Orexin Agonist Oveporexton Shows Promise for Narcolepsy Without Liver Toxicity
Topic: NEUROLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on June 11th, 2025
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The loss of orexin-producing neurons in the hypothalamus is the primary driver of narcolepsy, particularly type 1. While existing treatments focus on alleviating symptoms—such as promoting daytime wakefulness and reducing cataplexy—they do not target the underlying orexin deficiency. Previous attempts to develop orexin receptor agonists have been hampered by the need for intravenous delivery and concerns over liver toxicity. With funding from Takeda, a new study explored the use of oveporexton, a blood-brain barrier–permeable, orally administered orexin agonist, for the treatment of narcolepsy.
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Tolebrutinib and Teriflunomide Yield Similar Outcomes in Relapsing Multiple Sclerosis
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on June 9th, 2025
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Current therapies for multiple sclerosis (MS) primarily aim to control the inflammation that leads to white matter lesions. Among the more than 20 approved treatments, anti-CD20 monoclonal antibodies have proven effective in reducing lesion formation and preventing relapses. However, these therapies have shown limited success in halting the progression of disability. To explore alternative approaches, Sanofi sponsored a series of studies to evaluate the effectiveness of tolebrutinib in preventing relapses in patients with MS.
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Positive Results for Brexpiprazole in Youth Schizophrenia
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on June 6th, 2025
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Schizophrenia in children often presents with more severe symptoms and a poorer prognosis compared to adults. While there are effective antipsychotic treatments available for children and adolescents, these agents tend to carry higher risks in younger patients. Recent studies have suggested that beyond dopamine, other monoamine neurotransmitters—such as norepinephrine and serotonin—also contribute to the pathophysiology of schizophrenia. With funding from Otsuka Pharmaceutical, a study was conducted to evaluate the use of brexpiprazole in managing pediatric schizophrenia.
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Lorundrostat Shows Promise in Drug-Resistant Hypertension
Topic: CARDIOLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on June 4th, 2025
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Despite the use of multidrug regimens, many patients with hypertension continue to struggle with blood pressure control. Emerging research suggests that aldosterone dysregulation may be a key driver of treatment-resistant hypertension. With funding from Mineralys Therapeutics, a study was conducted to evaluate lorundrostat, an aldosterone synthase inhibitor, for managing blood pressure in this population.
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BCG Revaccination Fails to Prevent TB Infection in Adolescents
Topic: INFECTIOUS DISEASE
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on June 2nd, 2025
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Tuberculosis continues to pose a major public health burden in Vietnam and around the world, causing over 1 million deaths annually. Although the bacille Calmette–Guérin (BCG) vaccine has been used for decades to prevent infection, its protective effect diminishes over time. There has been growing interest in exploring whether revaccination with BCG could restore immunity. With support from the Bill & Melinda Gates Foundation, a study was conducted to evaluate the impact of BCG revaccination on tuberculosis prevention.
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Direct Oral Anticoagulants vs. Vitamin K Antagonists in Cerebral Venous Thrombosis
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on May 30th, 2025
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The optimal anticoagulation strategy for patients with cerebral venous thrombosis remains a topic of ongoing debate. While direct oral anticoagulants are more convenient for patients and have been associated with lower rates of intracranial hemorrhage, vitamin K antagonists remain more cost-effective. Additionally, vitamin K antagonists are associated with lower gastrointestinal bleeding risk, and are preferred in patients with mechanical heart valves. Given the lack of consensus, a multinational observational study was undertaken with support from the Netherlands Thrombosis Foundation.
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Anti-IL-5 Therapy, Mepolizumab, Shows Promise in COPD Management
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on May 28th, 2025
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Eosinophilic inflammation plays a significant role in chronic obstructive pulmonary disease (COPD), with interleukin-5 (IL-5) driving eosinophil maturation and activation. To evaluate a targeted approach, GlaxoSmithKline sponsored a study examining the efficacy of mepolizumab—an anti-IL-5 monoclonal antibody—in managing COPD.
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Lepodisiran, a Small Interfering Therapy Significantly Lowers Lipoprotein(a) Level
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on May 26th, 2025
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Lipoprotein(a) [Lp(a)] is a key component in the formation of cholesterol-transporting LDL particles. Elevated serum concentrations of Lp(a) have been linked to a higher risk of cardiovascular mortality. In efforts to address this risk factor, Eli Lilly sponsored a study evaluating the effectiveness of lepodisiran, a novel therapy aimed at lowering Lp(a) levels.
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Tamuzimod, an S1PR1 Inhibitor, Shows Promise in Reducing Ulcerative Colitis Symptoms
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on May 23rd, 2025
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Chronic inflammation of the colonic epithelium underlies ulcerative colitis, a condition that can significantly impair quality of life and elevate the long-term risk of colorectal cancer. While various treatments are available, many fall short in preventing disease relapse or carry undesirable side effects. To explore new therapeutic options, a study funded by Ventyx Biosciences evaluated the potential of tamuzimod for managing ulcerative colitis.
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Cytisinicline Shows Promise as a Well-Tolerated and Effective Aid for Smoking Cessation
Topic: RESPIRATORY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on May 21st, 2025
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Smoking is one of the most prevalent risk factors contributing to millions of preventable deaths each year. While several smoking cessation aids such as bupropion and varenicline are currently available, their limited long-term effectiveness and notable side effect profiles highlight the need for new alternatives. Backed by funding from the biotechnology company Achieve Life Sciences, a clinical trial was conducted to evaluate the efficacy of cytisinicline in reducing nicotine cravings.
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Baloxavir Shows Promise in Reducing Household Transmission of Influenza
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on May 19th, 2025
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While often regarded as a seasonal inconvenience for healthy adults, influenza can pose a serious, even fatal, threat to children, the elderly, and immunocompromised individuals. Each flu season typically involves the circulation of four distinct influenza strains, all of which are included in the annually updated vaccine. However, because the vaccine formulation relies on predictive modeling of which strains will dominate, its effectiveness varies from year to year and can be suboptimal. Although antivirals for influenza are available, there is limited conclusive evidence supporting their ability to reduce transmission. In pursuit of new options, Roche sponsored a study to evaluate the potential of baloxavir to lower influenza contagiousness.
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Brensocatib Reduces Exacerbation Risk and Slows Lung Function Decline in Patients with Bronchiectasis
Topic: RESPIRATORY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on May 16th, 2025
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Patients with bronchiectasis typically present with a chronic cough and excessive sputum production. The progressive decline in lung function associated with this disease is largely driven by neutrophil-mediated inflammation and damage to the mucociliary membrane. Current clinical guidelines generally recommend the use of mucoactive agents to alleviate symptoms and antibiotics to prevent bacterial infections. Recently, a study funded by Insmed and published in The New England Journal of Medicine examined the use of brensocatib, a drug aimed at managing bronchiectasis by inhibiting neutrophil activity.
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Evaluating Tecovirimat in Hospitalized Patients With Monkeypox
Topic: INFECTIOUS DISEASE
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on May 14th, 2025
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Since its global spread during the 2022 outbreak, monkeypox has been effectively controlled in most parts of the world. However, cases have continued to rise in sub-Saharan Africa, particularly in the Democratic Republic of Congo (DRC). Currently, there is no approved specific antiviral treatment for monkeypox. In response to the growing burden, the United States National Institute of Allergy and Infectious Diseases (NIAID) partnered with the Congolese Ministry of Health to investigate the efficacy of tecovirimat as a treatment for monkeypox infection.
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B-Cell Depletion With Obinutuzumab & Standard Therapy in Lupus Nephritis
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on May 12th, 2025
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Lupus nephritis is a severe autoimmune condition in which the immune system produces antibodies that mistakenly target kidney cells, impairing their filtration function. Although new therapies such as belimumab and voclosporin have recently been approved by regulatory agencies in the United States and Europe, these treatments have shown limitations in clinical outcomes. Consequently, there remains an urgent need for alternative therapeutic options. With funding from Roche, a study was conducted to evaluate the efficacy and safety of obinutuzumab in the treatment of lupus nephritis.
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Dapagliflozin Reduces Heart Failure Worsening in Elderly Patients with Severe Aortic Stenosis
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on May 9th, 2025
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Many clinical guidelines in both the United States and Europe recommend the use of sodium-glucose cotransporter 2 (SGLT2) inhibitors for patients with heart failure, regardless of diabetes status. However, individuals with severe valvular heart disease requiring transcatheter aortic-valve implantation have largely been excluded from these studies. To address this gap, a study funded by the Carlos III Health Institute in Spain was conducted to evaluate the use of SGLT2 inhibitors in patients with severe aortic stenosis.
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Reduced-Dose Apixaban Effectively Prevents Venous Thromboembolism in Cancer Patients
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on May 7th, 2025
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Patients with cancer face a significantly higher risk of venous thromboembolism compared to their healthy counterparts. Although many current guidelines recommend continued anticoagulation throughout the duration of cancer, prolonged therapy increases the risk of bleeding complications. To explore an optimal dosing strategy, a study funded by Bristol-Myers Squibb was conducted to evaluate the efficacy and safety of different apixaban dosing regimens in preventing thromboembolism among cancer patients.
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Efficacy of Gepotidacin Versus Nitrofurantoin for the Treatment of Lower Urinary Tract Infections
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on May 5th, 2025
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Lower urinary tract infections are extremely common, with approximately half of all women worldwide reporting at least one episode during their lifetime. Although these infections are generally manageable with antibiotics, past misuse has contributed to the growing problem of antimicrobial resistance, highlighting the need for new treatment options. Gepotidacin is a novel therapeutic agent, and GlaxoSmithKline sponsored a study to compare its effectiveness to that of nitrofurantoin in treating urinary tract infections.
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Lenacapavir Outperforms Daily Emtricitabine–Tenofovir for HIV Prevention
Topic: INFECTIOUS DISEASE
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on May 2nd, 2025
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Although the global number of new HIV infections is declining, infections among men who have sex with men and transgender women are rising. Pre-exposure prophylaxis (PrEP) is an effective method to prevent HIV transmission, but it requires consistent adherence to maintain its efficacy. To explore alternative prevention strategies, a study funded by Gilead Sciences evaluated the use of lenacapavir for HIV prevention.
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Managing ESR1-Mutated ER-Positive Breast Cancer with Imlunestrant & Abemaciclib
Topic: ONCOLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on April 30th, 2025
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Estrogen receptor (ER)-positive breast cancer can be managed with ER antagonists like fulvestrant. However, fulvestrant’s requirement for intramuscular injection complicates treatment, necessitating clinic visits and limiting its convenience. Furthermore, its efficacy is reduced in patients with ESR1 mutations in the estrogen receptor. Imlunestrant is a newer, orally available ER antagonist. To evaluate its effectiveness, Eli Lilly sponsored a study combining imlunestrant with abemaciclib in managing ER-positive, HER2-negative breast cancer.
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Tezepelumab Shows Promise in Reducing Nasal Polyps and Symptoms in Chronic Rhinosinusitis
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on April 28th, 2025
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Chronic rhinosinusitis with nasal polyps is typically managed with glucocorticoids and biologic therapies targeting various components of the type 2 inflammatory pathway. However, current treatments are not universally effective, highlighting the need for therapies that act through alternative mechanisms. To address this gap, AstraZeneca sponsored a study to evaluate the efficacy of tezepelumab in treating this condition.
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Muvalaplin Effectively Lowers Lipoprotein(a) in Cardiovascular Patients
Topic: CARDIOLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on April 25th, 2025
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Lipoprotein(a) is critical for packaging and transporting cholesterol in the bloodstream via low-density lipoproteins. Elevated levels of lipoprotein(a) heighten the risk of atherosclerotic cardiovascular disease by promoting plaque buildup. With funding from Eli Lilly, a study was undertaken to evaluate the efficacy of Muvalaplin in controlling lipoprotein(a) levels.
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Comparing Oral Glucose-Lowering Agents and Insulin in Gestational Diabetes
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on April 23rd, 2025
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Insulin has long been the standard therapy for controlling blood glucose in women with gestational diabetes. While oral agents like metformin and glyburide offer a more convenient alternative due to their ease of administration, the American Diabetes Association has advised against their use because of limited data on the long-term safety for offspring. To address this issue, the Australian National Health and Medical Research Council sponsored a study comparing the effectiveness of oral glucose-lowering agents with insulin for managing gestational diabetes.
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Preventing Recurrent Bacterial Vaginosis by Treating Male Sexual Partners with Combined Oral and Topical Antibiotics
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on April 21st, 2025
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Bacterial vaginosis is marked by a disruption of the normal vaginal microbiota, and previous research suggests that the penile microbiome of a male partner may predict the occurrence of bacterial vaginosis in the female partner. Funded by the National Health and Medical Research Council of Australia, a study was conducted to evaluate whether treating the male partner could help prevent recurrence in women.
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Simvastatin and Rifaximin Combination Therapy to Manage Decompensated Liver Cirrhosis
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on April 18th, 2025
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Decompensated liver cirrhosis represents the most advanced stage of liver damage, marked by extensive scarring and significantly reduced liver function. This condition can ultimately progress to acute liver failure and death, and there are currently no therapies available to prevent its progression. Funded by the European Union, a study was conducted to evaluate the use of simvastatin and rifaximin in managing liver cirrhosis.
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Comparative Efficacy of 7-Day versus 14-Day Antibiotic Regimens for Bloodstream Infections
Topic: INFECTIOUS DISEASE
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on April 16th, 2025
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Bloodstream infections can be treated with antibiotics, but there is little consensus on the optimal treatment duration. A short-term, 7-day regimen may not be sufficient to eradicate the bacteria and might lead to the selection of resistant strains, while a longer, 14-day regimen could be excessive—resulting in adverse events, secondary infections, increased resistance pressure on non-pathogens, and unnecessary resource use. To answer this question, the Canadian Institutes of Health Research sponsored a study to determine the optimal treatment duration.
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Treating Chronic Spontaneous Urticaria by Blocking Histamine Release with Remibrutinib
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on April 14th, 2025
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Chronic spontaneous urticaria is an allergic condition marked by unpredictable itching and hives, with no identifiable trigger. This allergic reaction results from mast cell degranulation. While second-generation H1 antihistamines are the most commonly prescribed treatment, up to 75% of patients may not respond even at maximum doses. Novartis sponsored a study to evaluate the effectiveness of remibrutinib, a BTK inhibitor, in managing urticaria.
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High-Dose Vitamin D Supplementation to Manage and Prevent Multiple Sclerosis
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on April 11th, 2025
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In patients with multiple sclerosis, low levels of vitamin D are linked to an increased risk of relapse, a greater disease burden, and more brain lesions. Vitamin D modulates the immune system by reducing lymphocyte differentiation and limiting the migration of immune cells across the blood-brain barrier. Based on this hypothesis, a study funded by the French Ministry of Health was conducted to assess the potential of vitamin D in managing multiple sclerosis and preventing relapses.
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Long-Term Tirzepatide Therapy Yields Significant Weight Loss and Cardiometabolic Benefits
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on April 9th, 2025
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Obesity is closely linked to the development of type 2 diabetes, a condition marked by significant beta cell dysfunction and insulin resistance. Weight management—whether through pharmacological interventions or lifestyle changes—has been proven to lower the risk of diabetes. Numerous studies have highlighted the weight loss benefits of tirzepatide, and a study funded by Eli Lilly has explored its potential for treating obesity and preventing diabetes.
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Using Lactin-V Probiotic to Prevent Recurrent Bacterial Vaginosis after Metronidazole Treatment
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on April 7th, 2025
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Bacterial vaginosis is a common condition that many women experience. Although it can be treated with antibiotics, recurrences are frequent, and if not managed effectively, the condition can lead to secondary infections and subsequent reproductive complications, imposing significant physical and emotional burdens. Funded by the United States National Institutes of Health, a study was conducted to explore the use of an intravaginal probiotic to prevent recurrent bacterial vaginosis.
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Sipavibart vs. Tixagevimab/Cilgavimab for COVID-19 Prevention in Immunocompromised Patients
Topic: COVID-19
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on April 4th, 2025
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Although COVID-19 vaccines have been highly effective, many immunocompromised individuals are unable to benefit from their protection. To address this, antibody combinations such as tixagevimab and cilgavimab—targeting the viral spike protein—have been utilized. However, the emergence of resistant variants has created a need for novel treatments. Funded by AstraZeneca, a study was conducted to evaluate the use of sipavibart in preventing COVID-19 infection.
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Potential Usage of Acetylcholine Muscarinic 1 Receptor Agonist to Manage Parkinson Disease
Topic: NEUROLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on April 2nd, 2025
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Acetylcholine deficiency is linked to Parkinson’s disease and has been associated with increased stride time variability and a higher risk of falls. Normally, acetylcholine is released into the synaptic cleft to activate neighboring neurons, and its signaling is terminated by acetylcholinesterase, which degrades the neurotransmitter. However, acetylcholinesterase inhibitors have not reduced the disease burden and often lead to unacceptable side effects. To address this, a study funded by Takeda Pharmaceutical was conducted to assess TAK-071, a novel muscarinic acetylcholine 1 receptor agonist, for managing Parkinson’s disease.
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