Investigating the Effect of Ensitrelvir in Treating Infection with the Omicron Subvariants of SARS-CoV-2
Topic: COVID-19
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Reviewed & translated by Dat Tien Nguyen, B.A, ScM.
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Posted on June 28th, 2024
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Most of the current clinical guidelines recommend the usage of remdesivir, molnupiravir, or the combination of ritonavir and nirmatrelvir to manage severe SARS-CoV-2 infection. However, studies that proved the effectiveness of these antivirals were conducted before Omicron subvariants became dominant. With the concern that the Omicron subvariants contains mutation that would negate the effect of current recommended treatment, a study was conducted to assess the effectiveness of ensitrelvir - a protease inhibitor that had proven to be effective against Omicron in animal studies.
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Association Between Maternal Hepatitis B Infection and Congenital Heart Defects
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Reviewed & translated by Dat Tien Nguyen, B.A, ScM.
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Posted on June 26th, 2024
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It has been well documented that maternal infection such as rubella virus, cytomegalovirus, and coxsackievirus can increase the risk of congenital heart defects (CHD). However, there is a limited number of studies that examine the effect of Hepatitis B infection on fetal development. A study recently published in the Journal of the American Medical Association had reported on the association between maternal Hepatitis B and congenital heart defects in the offspring.
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Increase the Effectiveness of E-Cigarette Cessation with Cytisinicline
Topic: RESPIRATORY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on June 24th, 2024
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With the increase in popularity in vaping and e-cigarette containing nicotine, regulatory agencies have identified that there is a gap in knowledge on the effectiveness of nicotine replacement therapy on e-cigarette cessation. Cytisinicline is an agonist that can inhibit the α4β2 nicotinic acetylcholine receptors which can reduce the dependence on nicotine. As a result, the National Institute of Drug Abuse had funded a study to assess the efficacy of cytisinicline on vaping cessation.
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Supplementation of Krill Oil in Patients with Knee Osteoarthritis
Topic: ORTHOPEDIC
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on June 21st, 2024
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Previous study had found that the supplementation of omega-3 polyunsaturated fatty acid can reduce inflammation. Compared to normal fishes, oil from Antarctic krill has a higher concentration of omega-3 fatty acids and it also contains astaxanthin, an antioxidant that can further reduce inflammation. Therefore, the National Health and Medical Research Council of Australia had sponsored a study to examine the effectiveness of krill oil in reducing inflammation and improving the health of patients living with knee osteoarthritis.
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Benzodiazepines usage during pregnancy and the risk of miscarriage
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on June 19th, 2024
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Benzodiazepines are frequently prescribed to treat anxiety and insomnia in pregnant women. However, the molecule can cross the placental barrier, so there has been concern that the substance can increase the risk of abnormal fetal development and miscarriage. Recent studies that examine this association contain several confounders such as maternal comorbidities, lifestyle, and the severity of anxiety and insomnia. Thus, a population-wide study was conducted to examine the in utero effect of benzodiazepines.
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Preventing acute pancreatitis caused by hypertriglyceridemia with an oligonucleotide targeting APOC-3 protein, Olezarsen
Topic: CARDIOLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on June 17th, 2024
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Familial chylomicronemia syndrome increases the risk of acute pancreatitis due to the high level of triglycerides. In the body, chylomicron and VLDL lipoproteins are responsible for trafficking triglycerides, and they possess APOC3 protein to prevent degradation. Olezarsen is an antisense oligonucleotide that can inhibit the expression of APOC3 and promote triglyceride clearance. Therefore, a study was conducted to examine the effect of Olezarsen on the risk of pancreatitis in patients with familial chylomicronemia syndrome.
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Promoting LDL Cholesterol Clearance in Pediatric Patients with Heterozygous Familial Hypercholesterolemia with Alirocumab
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on June 14th, 2024
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Statin and other lipid-lowering therapies are frequently used to control the cholesterol-carrying low-density lipoprotein (LDL-C) in pediatric patients with familial cholesterolemia. PSCK9 plays an important role in maintaining a high LDL-C level by destroying the cellular receptor that would clear LDL-C from blood. Alirocumab is an antibody that can inhibit PSCK9, and a study was conducted to assess its capability in promoting LDL-C clearance to manage heterozygous familial hypercholesterolemia in children.
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Examine the Effect of 2nd Generation Antipsychotic Medications on Children and Young Adults
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on June 12th, 2024
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In adults, it has been characterized that antipsychotic medications increase the risk of cardiovascular problems, respiratory failure, and metabolic dysfunction, and death. The usage of 2nd generation antipsychotic agents has been increased in children and adolescents, frequently, in the form of off-label use. Thus, the National Institute for Child Health and Human Development had sponsored a study to investigate the impact of antipsychotic medications on the health of children and adolescents.
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Amphetamine/Dextroamphetamine and Methylphenidate Usage during Pregnancy and the Risk of Neurodevelopmental Disorders in Children
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on June 10th, 2024
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With the increase in prevalence of attention deficit hyperactivity disorder (ADHD) in adults, the amount of stimulant medication being prescribed had also increased. However, there is a limited number of studies that investigate the effect of these medications on the neurodevelopment of a fetus. A study, recently published in the Journal of the American Medical Association, investigates the possible association between maternal usage of stimulant medication to treat ADHD and the risk of neurodevelopmental disorders in the child.
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Possibility of Using Epicutaneous Immunotherapy to Induce Tolerance in Children and adolescent Affected with Cow’s Milk Allergy
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on June 7th, 2024
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Despite the major reduction in the quality of life of those who are affected by cow’s milk allergy, there are currently no approved biological interventions besides avoidance. Epicutaneous exposure with the allergen had been tested as a management tool for peanut allergy. An article, recently published in the Journal of the American Medical Association, had investigated the usage of epicutaneous immunotherapy containing milk allergen to manage cow’s milk allergy in children and adolescents.
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Investigating the Effect of Early Iron Supplementation in the Neurodevelopment of Breastfed Infants
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on June 5th, 2024
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Infantile iron deficiency is a common global problem, which is more severe in resource-limited communities. Anemia caused by iron deficiency can potentially interfere with neurodevelopment and cause cognitive impairment and behavioral problems. Since the iron content of breast milk is low, there is a debate on the necessity of iron supplementation. To fill this gap in knowledge, a study was conducted in Poland and Sweden to investigate the effect of daily iron supplementation on early cognitive development.
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Using Andexanet Alfa as an Antidote to Manage Intracranial Hemorrhage Caused by Factor Xa Inhibitors
Topic: CARDIOLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on June 3rd, 2024
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To prevent thrombosis, factor Xa inhibitors are usually used. However, the anticoagulant increases the risk of hemorrhage. To prevent this unwanted effect, antagonists for the inhibitor can potentially be used as an antidote. Andexanet alfa is an inactive form of factor Xa that can bind to and neutralize the anticoagulant. A study was conducted to assess the effectiveness of andexanet alfa in preventing mortality and reducing morbidity associated with intracerebral caused by factor Xa inhibitors.
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Concurrent Usage of Nivolumab and Platinum-based Chemotherapy before and after Surgery for Resectable Non–Small-Cell Lung Cancer
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on May 31st, 2024
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Nivolumab is an monoclonal antibody that enhances the immune clearance of tumor cell by inhibiting the PD-1 receptor. Neoadjuvant usage of nivolumab and platinum-based chemotherapy had significantly reduced the risk of death and disease recurrence in patients with resectable non–small-cell lung cancer. As a result, a study investigated the perioperative usage of nivolumab, before and after surgery, can improve clinical outcome by neutralizing residual tumor cells and inhibiting micrometastasis.
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Managing Hypertriglyceridemia with Olezarsen, an oligonucleotide that neutralize Apoprotein C-III mNRA
Topic: CARDIOLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on May 29th, 2024
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Hypertriglyceridemia is associated with severe health outcomes such as acute pancreatitis, and there are currently not many available pharmaceutical interventions. Apoprotein C-III (APOC3) is a naturally producing agent that increases the level of triglycerides in blood by inhibiting lipoprotein lipase and hepatic clearance. Therefore, a new study was conducted to assess the effect of Olezarsen, a oligonucleotide that can neutralize APOC3 mRNA, in managing hypertriglyceridemia.
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Concurrent usage of beta-blocker and other cardiovascular medication in managing health post myocardial infarction
Topic: CARDIOLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on May 27th, 2024
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The usage of beta-blockers following a myocardial infarction episode had been reported to reduce the risk of death by 20%. However, the recommendation of beta-blocker usage was issued before the advent of current cardiovascular interventions. Thus, following the recommendation of the Cochrane review, the Swedish Research Council had funded a study to assess the concurrent effect of beta-blocker and other medications on managing cardiovascular health after myocardial infarction.
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Using Vosoritide to Treat Hypochondroplasia by Inhibiting the Fibroblast Growth Factor Receptor 3 Signaling Pathway
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on May 24th, 2024
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Hypochondroplasia is hallmarked by the over-activation of the fibroblast growth factor receptor 3 (FGFR3) which disrupts endochondral ossification. Vosoritide is an analogue of c-type natriuretic peptide that can bind to and inhibit the mitogen-activated protein kinase pathway downstream from FGFR3 activation. A study recently published on the Lancet had investigated the effect of Vosoritide on treating hypochondroplasia.
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Using monoclonal antibody targeting the conserved Plasmodium falciparum circumsporozoite protein as a prophylaxis for malaria
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on May 22nd, 2024
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Currently, the World Health Organization has issued recommendations for two types of malaria vaccines - RTS,S/AS01 and R21/ Matrix-M - for pediatric usage. In addition, chemoprophylaxis is recommended for infants and children with severe anemia. CIS43LS is a monoclonal antibody that can bind to the conserved Plasmodium falciparum circumsporozoite protein and neutralize the parasite. Previous studies had shown that CIS43LS has a high efficacy in preventing infection in adults. Thus, the National Institute of Allergy and Infectious Disease had sponsored a study to assess the efficacy of CIS43LS in preventing malaria in children.
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Evaluating the effect of nutritional support in moderate-to-late preterm infants
Topic: PEDIATRIC
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on May 20th, 2024
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The risk of developmental delay, cardiometabolic disease and death is significantly higher in moderate-to-late preterm children. However, there is currently a research gap in the nutritional needs of this population. Therefore, the Health Research Council of New Zealand had funded a study to examine the effectiveness of various nutritional support interventions on the body fat composition and the time to full enteral feeding of the preterm neonates.
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Empagliflozin as a Preventive Measure for Heart Failure Post-Myocardial Infarction
Topic: CARDIOLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on May 17th, 2024
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It had previously been observed that treatment of sodium–glucose cotransporter 2 (SGLT2) inhibitors help improve cardiovascular outcomes of heart failure patients with reduced left ventricular ejection fraction. Given the heightened risk of heart failure subsequent to a myocardial infarction episode, a study was initiated to explore the potential of empagliflozin as a preventative measure.
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Semaglutide Treatment Improves Clinical Outcomes in Obese Patients with Heart Failure
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on May 13th, 2024
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The rise in obesity rates has paralleled an increase in the occurrence of heart failure with preserved ejection fraction. Type 2 diabetes (T2DM) is closely linked to both these conditions, and individuals with comorbid heart failure and T2DM experience a greater disease burden and adverse hemodynamics. A recent study aimed to evaluate the potential of Semaglutide, a glucagon-like peptide 1 receptor antagonist commonly prescribed for T2DM, in the management of heart failure with preserved ejection fraction among obese patients.
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Exploring the Efficacy of D-Mannose in Preventing Recurrent Urinary Tract Infections
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on May 10th, 2024
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D-mannose is a naturally occurring isomer of glucose, and it can bind to bacterial fimbriae to inhibit adherence to epithelial cells. A recent publication in the Journal of the American Medical Association explored its potential in preventing uropathogen colonization in cases of recurrent urinary tract infection.
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Assessing Guselkumab Efficacy in Treating Pityriasis Rubra Pilaris
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on May 8th, 2024
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Pityriasis rubra pilaris is a rare inflammatory condition that shares similar immunological pathways with psoriasis such as interleukin-23 overexpression and T-helper 17 activation. Psoriasis can be treated with guselkumab, an antibody that can bind to IL-23p19, and the pharmaceutical company Janssen had sponsored a study to assess its efficacy to treat pityriasis rubra pilaris.
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Comparative Study of Oral and Topical Minoxidil for Androgenetic Alopecia in Men
Topic: DERMATOLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on May 6th, 2024
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To treat androgenetic alopecia in men, the only treatments approved by the US Food and Drug Administration are oral finasteride and topical minoxidil. However, their usage had been linked with adverse sexual effects and scalp irritation. Consequently, the Brazilian Dermatology Society initiated a study to explore the feasibility of employing oral minoxidil for managing androgenetic alopecia.
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Assessing Azithromycin's Impact on Bronchopulmonary Dysplasia in Preterm Infants
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on May 3rd, 2024
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Because of their premature birth, infants born before 30 gestational weeks are at a heightened risk of developing bronchopulmonary dysplasia, a condition marked by interrupted lung development. Factors such as pulmonary colonization with Ureaplasma bacteria and inflammation mediated by neutrophils contribute to this risk. Azithromycin, a macrolide antibiotic, has the ability to combat bacteria and has been linked to reduced neutrophil activity and chemotaxis. Consequently, a study was undertaken to evaluate the impact of azithromycin on managing bronchopulmonary dysplasia in preterm infants.
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The Efficacy of Plozasiran in Managing Hypertriglyceridemia
Topic: CARDIOLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on May 1st, 2024
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Hypertriglyceridemia correlates with an increased likelihood of developing atherosclerotic cardiovascular disease, nonalcoholic fatty liver, and acute pancreatitis. The protein APOC3 is implicated in this condition due to its role in impeding the breakdown of triglyceride-rich lipoproteins and chylomicrons. Plozasiran, a small-interfering RNA, targets and degrades mRNA encoding the APOC3 protein. Consequently, a study was undertaken to evaluate its effectiveness in addressing hypertriglyceridemia.
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Investigating the efficacy of Alectinib, an ALK inhibitor, in ALK-Positive Non-Small-Cell Lung Cancer
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on April 29th, 2024
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Approximately 5% of all cases of non-small-cell lung cancer (NSCLC) exhibit rearrangement to the anaplastic lymphoma kinase (ALK) gene. This specific subset of NSCLC can be treated with platinum-based combination chemotherapy; however, this regimen has modest improvements to the survival rate and it has a relatively high risk of disease recurrence. Alectinib is an ALK inhibitor, and a study has been conducted to assess its efficacy in managing ALK-positive NSCLC.
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Assessing Nirmatrelvir-Ritonavir Combination in SARS-CoV-2 Treatment for Vaccinated and Unvaccinated Patients
Topic: COVID-19
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on April 24th, 2024
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Currently, the antiviral combination of nirmatrelvir and ritonavir are widely used to treat SARS-CoV-2 infection. While the efficacy of this drug has been evaluated in unvaccinated adults, its efficacy rate in a population comprising both vaccinated and unvaccinated individuals remains uncertain. A recent study, featured in the New England Journal of Medicine, investigated the interplay between nirmatrelvir and SARS-CoV-2 vaccination.
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Assessing the Efficacy of Lixisenatide in Managing Parkinson’s Disease Progression
Topic: NEUROLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on April 22nd, 2024
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The majority of current biological interventions for Parkinson’s disease focus on dopamine replacement therapy, as dopamine deficiency is a central feature of the condition. However, recent research has identified a heightened risk of Parkinson's in individuals with type 2 diabetes. Interestingly, individuals treated with glucagon-like peptide 1 receptor (GLP-1R) agonists appear to have the lowest risk of developing Parkinson's. In response to these findings, the French Ministry of Health initiated a study to investigate the potential of using Lixisenatide, a GLP-1R agonist commonly prescribed for type 2 diabetes, as a treatment for Parkinson’s disease.
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Combination Therapy with Ribociclib and Nonsteroidal Aromatase Inhibitors for HR-Positive, HER2-Negative Breast Cancer
Topic: ONCOLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on April 18th, 2024
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Breast cancer tumors that express hormone receptors (HR) but not epidermal growth factor receptor 2 (HER2) constitute the most prevalent type of breast cancer. Ribociclib, an agent that inhibits cyclin-dependent kinases 4 and 6, has shown efficacy in suppressing tumor progression and is commonly used in the treatment of advanced-stage breast cancer. Consequently, a study was conducted to evaluate the potential of Ribociclib in treating early-stage HR-positive, HER2-negative breast cancer.
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Investigating Antiseizure Medication Use During Pregnancy and Autism Risk
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on April 17th, 2024
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During pregnancy, the administration of medication can significantly influence fetal development. Expectant mothers with epilepsy often require antiseizure medication throughout their pregnancy to manage their condition. Numerous studies have indicated that certain medications like topiramate, valproate, and lamotrigine may have teratogenic effects, potentially resulting in adverse neurodevelopmental outcomes. Consequently, the United States National Institute of Mental Health funded a comprehensive study to investigate the correlation between maternal use of antiseizure medication and the risk of autism spectrum disorder in their children.
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Effectiveness of Maternal Immunization with the RSVPreF3-Mat Vaccine in Preventing Childhood RSV Infection
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on April 15th, 2024
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Maternal immunization has proven to be an efficient strategy for shielding young children from diseases. RSVPreF3-Mat is a subunit vaccine targeting RSV that has been designed specifically for maternal administration. Its formulation comprises the RSV fusion protein in its prefusion conformation. GlaxoSmithKline, a pharmaceutical company, supported a study aimed at evaluating the efficacy of RSVPreF3-mat in preventing RSV infection among children.
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Enhanced Antitumor Activity against Urothelial Carcinoma with the Enfortumab Vedotin and Pembrolizumab Combination
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on April 12th, 2024
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Platinum-based chemotherapy has long been the conventional therapy for urothelial carcinoma, but its efficacy remains limited, resulting in a low 5-year survival rate. Recent investigations have shown promising outcomes with the combination of enfortumab vedotin, an antibody targeting nectin-4 - a cell adhesion molecule overexpressed on tumor cells - and pembrolizumab, a PD-1 inhibitor. In light of these findings, a larger-scale study was undertaken to evaluate the enhanced antitumor activity of the enfortumab vedotin and pembrolizumab combination against urothelial carcinoma.
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Assessing Omalizumab Efficacy in Treating Multiple Food Allergies
Topic: ALLERGY & IMMUNOLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on April 10th, 2024
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Food allergy is a common condition that affects individuals of all ages, with many of them having allergies to multiple types of food. Currently, only peanut allergy is treatable with oral immunotherapy but it is associated with many adverse events and cannot address multiple types of food allergies. Omalizumab is an antibody that can neutralize IgE and has been approved for treating allergic asthma and urticaria. Thus, the National Institute of Allergy and Infectious Diseases had funded a study to assess the usage of Omalizumab in treating multiple food allergies.
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Potential Cognitive Function Decline Following SARS-CoV-2 Infection
Topic: COVID-19
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on April 8th, 2024
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There have been widespread reports indicating a potential link between prior SARS-CoV-2 infection and a reduction in cognitive and memory function. However, empirical evidence supporting this association remains scarce. Consequently, the National Institute for Health and Care Research, situated in the United Kingdom, initiated an observational study aimed at elucidating the effects of SARS-CoV-2 infection on memory and cognitive function.
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Seladelpar Efficacy in Treating Primary Biliary Cholangitis
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on April 5th, 2024
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Primary biliary cholangitis, a rare liver disorder impacting the bile duct and leading to toxic bile acid buildup, currently has only one FDA-approved treatment: ursodeoxycholic acid. However, this medication is linked to significant adverse effects like pruritus and shows only a moderate response rate. Seladelpar, a novel agent capable of activating the proliferator–activated receptor Delta (PPAR-delta) to mitigate bile acid accumulation, underwent evaluation for its efficacy in treating primary biliary cholangitis in a recent study.
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Efficacy of Delayed Thrombolytic Tenecteplase Intervention in Ischemic Stroke
Topic: CARDIOLOGY
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on April 3rd, 2024
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Administering thrombolytic agents like alteplase within 4.5 hours of an ischemic stroke is currently the standard practice. The American Heart Association recommends using tenecteplase, a type of alteplase, for this purpose. However, the efficacy of thrombolytic agent administration after 4.5 hours from the onset of the disease remains poorly understood. Consequently, a study was conducted to evaluate the impact of delayed intervention.
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Assessing the Efficacy of Cefepime-Taniborbactam Combo in Complicated Urinary Tract Infections
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Reviewed by Dat Tien Nguyen, B.A, ScM.
Translated by Nhi Phuong Quynh Le, B.A |
Posted on April 1st, 2024
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Urinary tract infection (UTI) is a prevalent illness that can be successfully addressed with beta-lactam antibiotics like cefepime, a fourth-generation cephalosporin. Nonetheless, significant resistance has emerged against these antimicrobial agents, particularly in the form of beta-lactamase. Taniborbactam, a novel beta-lactamase inhibitor, has recently undergone evaluation in combination with cefepime for the treatment of UTIs in a recent study.
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